体外观察到阿奇霉素、克拉霉素、米诺环素或替加环素与抗真菌药物联合使用时对隐孢子虫具有协同作用。
In vitro synergism observed with azithromycin, clarithromycin, minocycline, or tigecycline in association with antifungal agents against Pythium insidiosum.
作者信息
Jesus Francielli P K, Ferreiro Laerte, Loreto Érico S, Pilotto Maiara B, Ludwig Aline, Bizzi Karine, Tondolo Juliana S M, Zanette Régis A, Alves Sydney H, Santurio Janio M
机构信息
Programa de Pós-Graduação em Ciências Veterinárias, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
出版信息
Antimicrob Agents Chemother. 2014 Sep;58(9):5621-5. doi: 10.1128/AAC.02349-14. Epub 2014 Jul 7.
Abstract
We describe here the in vitro activities of azithromycin, clarithromycin, minocycline, or tigecycline alone and in combination with amphotericin B, itraconazole, terbinafine, voriconazole, anidulafungin, caspofungin, or micafungin against 30 isolates of the oomycete Pythium insidiosum. The assays were based on the CLSI M38-A2 technique and the checkerboard microdilution method. The main synergisms observed were through the combination of minocycline with amphotericin B (73.33%), itraconazole (70%), and micafungin (70%) and of clarithromycin with micafungin (73.33%).
摘要
我们在此描述阿奇霉素、克拉霉素、米诺环素或替加环素单独以及与两性霉素B、伊曲康唑、特比萘芬、伏立康唑、阿尼芬净、卡泊芬净或米卡芬净联合使用时，对30株隐匿腐霉卵菌的体外活性。试验基于CLSI M38 - A2技术和棋盘微量稀释法。观察到的主要协同作用是米诺环素与两性霉素B（73.33%）、伊曲康唑（70%）和米卡芬净（70%）以及克拉霉素与米卡芬净（73.33%）的联合使用。
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Int J Antimicrob Agents. 2014 May;43(5):395-402. doi: 10.1016/j.ijantimicag.2013.12.009. Epub 2014 Jan 22.
2
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APMIS. 2014 May;122(5):412-7. doi: 10.1111/apm.12159. Epub 2013 Sep 6.
3
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6
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7
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9
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