Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan.
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan; Molecular and Biological Agricultural Sciences Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan; Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung 402, Taiwan.
Trends Plant Sci. 2014 Oct;19(10):647-55. doi: 10.1016/j.tplants.2014.06.004. Epub 2014 Jul 4.
Phosphate (Pi), which is indispensable for the structural and metabolic needs of plants, is acquired and translocated by Pi transporters. Deciphering the regulatory network of Pi signaling and homeostasis that involves the control of Pi transporters trafficking to, and their activity at, the plasma membrane provides insight into how plants adapt to environmental changes in Pi availability. Here, we review recent studies that revealed the involvement of microRNA399-PHOSPHATE 2 (PHO2) and microR827-NITROGEN LIMITATION ADAPTATION (NLA) modules in mediating the ubiquitination and degradation of PHOSPHATE TRANSPORTER 1 (PHT1) and/or PHOSPHATE 1 (PHO1). These discoveries show that miRNAs are an effective way for plants to monitor the turnover of Pi transporters in the membrane system by modulating the functioning of the membrane-associated ubiquitin machinery.
磷酸盐（Pi）是植物结构和代谢所必需的，它通过 Pi 转运蛋白获取和转运。解析涉及 Pi 转运蛋白向质膜运输及其活性的 Pi 信号和稳态的调控网络，为了解植物如何适应 Pi 供应变化的环境提供了线索。在这里，我们回顾了最近的研究，这些研究揭示了 microRNA399-PHOSPHATE 2（PHO2）和 microR827-NITROGEN LIMITATION ADAPTATION（NLA）模块在介导 PHOSPHATE TRANSPORTER 1（PHT1）和/或 PHOSPHATE 1（PHO1）的泛素化和降解中的作用。这些发现表明，miRNAs 是植物通过调节膜相关泛素机制的功能来监测膜系统中 Pi 转运蛋白周转的有效途径。
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