Wang Xuebing, Ma Shaolin, Liu Yang, Xu Wei, Li Zhanxia
Department of Center ICU, East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China,
Cell Biochem Biophys. 2014 Dec;70(3):1639-45. doi: 10.1007/s12013-014-0107-1.
This research is aimed to discover the influence and underling mechanism of combined infusion of arginine vasopressin with levosimendan on acute lung injury in rat septic shock with norepinephrine supplemented. The traditional fecal peritonitis-induced septic shock model was undergone in rats for study. It is observed that the combined infusion supplemented with norepinephrine brought about a lower mean pulmonary artery pressure; lower high-mobility group box 1 levels, pulmonary levels of interleukin-6, and arterial total nitrate/nitrite; lower apoptotic cells scores and total histological scores; but higher pulmonary gas exchange when compared with the separate infusion group and norepinephrine group. This therapy shows potential clinical beneficial assistance in sepsis-induced acute lung injury. The results suggest the mechanism of such effect is through abating pulmonary artery pressure, and more importantly suppressing inflammatory responses in lung when compared with norepinephrine infusion group and the separate infusion of levosimendan or vasopressin alone.
本研究旨在探讨在补充去甲肾上腺素的情况下，精氨酸加压素与左西孟旦联合输注对大鼠脓毒症休克急性肺损伤的影响及其潜在机制。采用传统的粪性腹膜炎诱导的脓毒症休克模型对大鼠进行研究。结果发现，与单独输注组和去甲肾上腺素组相比，补充去甲肾上腺素的联合输注导致平均肺动脉压更低；高迁移率族蛋白B1水平、肺组织白细胞介素-6水平和动脉总硝酸盐/亚硝酸盐水平更低；凋亡细胞评分和组织学总评分更低；但肺气体交换更好。该治疗方法在脓毒症诱导的急性肺损伤中显示出潜在的临床有益作用。结果表明，与去甲肾上腺素输注组以及单独输注左西孟旦或加压素相比，这种效应的机制是通过降低肺动脉压，更重要的是抑制肺内的炎症反应。
