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[继发性软骨肉瘤:放射病理学相关性]

[Secondary chondrosarcoma: radiopathological correlation].

作者信息

Lozano Martínez G A, Llauger Rosselló J

机构信息

Servicio de diagnóstico por la imagen,Hospital de la Santa Creu i Sant Pau , Barcelona, España.

Servicio de diagnóstico por la imagen,Hospital de la Santa Creu i Sant Pau , Barcelona, España.

出版信息

Radiologia. 2015 Jul-Aug;57(4):344-59. doi: 10.1016/j.rx.2014.04.004. Epub 2014 Jul 4.

DOI:10.1016/j.rx.2014.04.004
PMID:25002353
Abstract

Chondrosarcomas are malignant bone tumors originating in cartilage. Chondrosarcoma is the third most common malignant bone tumor after multiple myeloma and osteosarcoma. About 75% of chondrosarcomas are primary lesions. The remaining 25% belong to special categories such as histologic variants and secondary forms. A secondary chondrosarcoma is one that appears in a pre-existing benign chondral lesion; the different types of secondary chondrosarcomas include solitary osteochondroma, multiple osteochondromatosis, enchondroma, the different types of enchondromatosis, and primary synovial chondromatosis. The incidence of this malignant transformation varies widely in function of the type of lesion. In this article, we discuss and illustrate the different types of secondary chondrosarcomas, placing special emphasis on the imaging findings that should alert to these lesions and give radiologists a key role in the diagnosis, management, and follow-up of these patients.

摘要

软骨肉瘤是起源于软骨的恶性骨肿瘤。软骨肉瘤是继多发性骨髓瘤和骨肉瘤之后第三常见的恶性骨肿瘤。约75%的软骨肉瘤为原发性病变。其余25%属于特殊类型,如组织学变异型和继发性类型。继发性软骨肉瘤是指出现在先前存在的良性软骨病变中的肿瘤;不同类型的继发性软骨肉瘤包括孤立性骨软骨瘤、多发性骨软骨瘤病、内生软骨瘤、不同类型的内生软骨瘤病以及原发性滑膜软骨瘤病。这种恶性转化的发生率因病变类型而异。在本文中,我们讨论并阐述了不同类型的继发性软骨肉瘤,特别强调了应提醒注意这些病变的影像学表现,并赋予放射科医生在这些患者的诊断、管理和随访中关键作用。

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引用本文的文献

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[Chondrosarcoma arising in solitary osteochondroma: a case study].[孤立性骨软骨瘤中发生的软骨肉瘤:病例报告]
Pan Afr Med J. 2019 Mar 26;32:143. doi: 10.11604/pamj.2019.32.143.15533. eCollection 2019.
2
Long non-coding RNA BCAR4 promotes chondrosarcoma cell proliferation and migration through activation of mTOR signaling pathway.长链非编码RNA BCAR4通过激活mTOR信号通路促进软骨肉瘤细胞增殖和迁移。
Exp Biol Med (Maywood). 2017 May;242(10):1044-1050. doi: 10.1177/1535370217700735. Epub 2017 Apr 11.