被监禁的静脉注射吸毒者中乙肝标志物的血清流行率。

Seroprevalence of hepatitis B markers among incarcerated intravenous drug users.

作者信息

Nokhodian Zary, Yaran Majid, Adibi Peyman, Kassaian Nazila, Meshkati Marjan, Ataei Behrooz

机构信息

Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

J Res Med Sci. 2014 Mar;19(Suppl 1):S13-6.

PMID:25002887

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4078382/

Abstract

BACKGROUND

Drug injection is one of the most prominent risk factors for transmission of viral hepatitis. Prevalence of hepatitis B virus (HBV) is generally higher in prisoners compared with the general population. The object of this study was to assess the markers of HBV and related risk factors among intravenous drug users (IVDU) in prisoners.

MATERIALS AND METHODS

Through a cross-sectional study in 2012 HBV infection and its risk factors were assessed in prisoners with a history of intravenous drug use in Isfahan, Iran. A checklist was fulfilled for each participant and 5 ml blood was taken from each subject. Sera were analyzed for markers of the hepatitis B: Hepatitis B virus surface antigen (HBsAg), antibody to hepatitis B virus surface antigen (HBsAb) and hepatitis B virus core antibody (HBcAb) by ELISA. We used Chi-square test and logistic regression model to analyze data and P < 0.05 was considered to be significant.

RESULTS

All of the studied participants (n = 970) were men. The mean ± standard deviation of the age of the subjects was 32.61 ± 8.1 years and the majority of them had less than high school education. More than 40% of these men had a history of injection drug inside prison and 2.27% of them self-reported history of HBV infection. Of the 970 IVDU, 32 (3.3%) were positive for HBsAg. Among HBsAg + subjects, 23 (71.88%) were HBcAb+. 120 (12.37%) were found positive for isolated HBsAb, 45 (4.64%) for isolated HBcAb and 67 (6.9%) for both HBsAb and HBcAb. History of sharing needle (odds ratio: 2.25, 95% confidence interval: 1.09-4.65) had a significant association with HBsAg positivity.

CONCLUSION

The results suggest that history of sharing needle had a significant association with HBsAg positivity. It seems that educational programs for injecting drug related behaviors, especially syringe sharing, are needed for IVDU.

摘要

背景

药物注射是病毒性肝炎传播的最主要危险因素之一。与普通人群相比，囚犯中乙肝病毒（HBV）的感染率通常更高。本研究的目的是评估囚犯中静脉吸毒者（IVDU）的HBV标志物及相关危险因素。

材料与方法

通过2012年的一项横断面研究，对伊朗伊斯法罕有静脉吸毒史的囚犯进行HBV感染及其危险因素评估。为每位参与者填写一份清单，并从每位受试者采集5毫升血液。采用酶联免疫吸附测定法（ELISA）分析血清中的乙肝标志物：乙肝病毒表面抗原（HBsAg）、乙肝病毒表面抗原抗体（HBsAb）和乙肝病毒核心抗体（HBcAb）。我们使用卡方检验和逻辑回归模型分析数据，P < 0.05被认为具有统计学意义。

结果

所有研究参与者（n = 970）均为男性。受试者的平均年龄±标准差为32.61 ± 8.1岁，他们中的大多数人学历低于高中。这些男性中超过40%有在监狱内注射毒品的历史，2.27%的人自述有HBV感染史。在970名IVDU中，32人（3.3%）HBsAg呈阳性。在HBsAg阳性受试者中，23人（71.88%）HBcAb呈阳性。120人（12.37%）单独的HBsAb呈阳性，45人（4.64%）单独的HBcAb呈阳性，67人（6.9%）HBsAb和HBcAb均呈阳性。共用针头史（比值比：2.25，95%置信区间：1.09 - 4.65）与HBsAg阳性有显著关联。