Karimkhani Chante, Boyers Lindsay N, Margolis David J, Naghavi Mohsen, Hay Roderick J, Williams Hywel C, Naldi Luigi, Coffeng Luc E, Weinstock Martin A, Dunnick Cory A, Pederson Hannah, Vos Theo, Murray Christopher J L, Dellavalle Robert P
College of Physicians and Surgeons, Columbia University, New York, New York, United States of America.
School of Medicine, Georgetown University, Washington, District of Columbia, United States of America.
PLoS One. 2014 Jul 8;9(7):e102122. doi: 10.1371/journal.pone.0102122. eCollection 2014.
Disease burden data helps guide research prioritization.
To determine the extent to which grants issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) reflect disease burden, measured by disability-adjusted life years (DALYs) from Global Burden of Disease (GBD) 2010 project.
Two investigators independently assessed 15 skin conditions studied by GBD 2010 in the NIAMS database for grants issued in 2013. The 15 skin diseases were matched to their respective DALYs from GBD 2010.
The United States NIAMS database and GBD 2010 skin condition disability data.
MAIN OUTCOME(S) AND MEASURE(S): Relationship of NIAMS grant database topic funding with percent total GBD 2010 DALY and DALY rank for 15 skin conditions.
During fiscal year 2013, 1,443 NIAMS grants were issued at a total value of $424 million. Of these grants, 17.7% covered skin topics. Of the total skin disease funding, 82% (91 grants) were categorized as "general cutaneous research." Psoriasis, leprosy, and "other skin and subcutaneous diseases" (ie; immunobullous disorders, vitiligo, and hidradenitis suppurativa) were over-represented when funding was compared with disability. Conversely, cellulitis, decubitus ulcer, urticaria, acne vulgaris, viral skin diseases, fungal skin diseases, scabies, and melanoma were under-represented. Conditions for which disability and funding appeared well-matched were dermatitis, squamous and basal cell carcinoma, pruritus, bacterial skin diseases, and alopecia areata.
Degree of representation in NIAMS is partly correlated with DALY metrics. Grant funding was well-matched with disability metrics for five of the 15 studied skin diseases, while two skin diseases were over-represented and seven were under-represented. Global burden estimates provide increasingly transparent and important information for investigating and prioritizing national research funding allocations.
疾病负担数据有助于指导研究重点的确定。
确定美国国立关节炎、肌肉骨骼和皮肤病研究所（NIAMS）发放的研究经费在多大程度上反映了疾病负担，该负担以全球疾病负担（GBD）2010项目中的伤残调整生命年（DALYs）来衡量。
两名研究人员独立评估了NIAMS数据库中2013年发放的、GBD 2010所研究的15种皮肤病的研究经费。将这15种皮肤病与其在GBD 2010中各自的伤残调整生命年进行匹配。
美国NIAMS数据库和GBD 2010皮肤病伤残数据。
NIAMS研究经费数据库主题资助与15种皮肤病在GBD 2010总伤残调整生命年百分比及伤残调整生命年排名之间的关系。
2013财年，NIAMS发放了1443项研究经费，总价值4.24亿美元。其中，17.7%的经费涉及皮肤相关主题。在所有皮肤病研究经费中，82%（91项经费）被归类为“一般皮肤研究”。与疾病负担相比，银屑病、麻风病以及“其他皮肤和皮下疾病”（即免疫性大疱性疾病、白癜风和化脓性汗腺炎）在经费资助方面占比过高。相反，蜂窝织炎、褥疮、荨麻疹、寻常痤疮、病毒性皮肤病、真菌性皮肤病、疥疮和黑色素瘤的经费资助占比过低。经费资助与疾病负担匹配较好的疾病有皮炎、鳞状和基底细胞癌、瘙痒症、细菌性皮肤病和斑秃。
NIAMS的资助占比程度与伤残调整生命年指标部分相关。在所研究的15种皮肤病中，有5种疾病的经费资助与疾病负担指标匹配良好，2种皮肤病的资助占比过高，7种皮肤病的资助占比过低。全球疾病负担估计为调查和确定国家研究经费分配重点提供了越来越透明且重要的信息。
