利用转基因小鼠的实时多光子成像技术对一种脑渗透性荧光分子进行表征及对Aβ实质斑块进行可视化观察。

Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice.

作者信息

Sundaram G S M, Garai Kanchan, Rath Nigam P, Yan Ping, Cirrito John R, Cairns Nigel J, Lee Jin-Moo, Sharma Vijay

机构信息

BRIGHT Institute, Molecular Imaging Center, ‡Mallinckrodt Institute of Radiology, §Department of Biomedical Engineering, ∥Departments of Neurology and ⊥Pathology & Immunology, #Knight Alzheimer's Disease Research Center, and ∇Hope Center for Neurological Disorders, Washington University School of Medicine , St. Louis, Missouri 63110, United States.

出版信息

Org Lett. 2014 Jul 18;16(14):3640-3. doi: 10.1021/ol501264q. Epub 2014 Jul 8.

Emerging paradigms mandate discovery of imaging agents for diagnosing Alzheimer's disease (AD) prior to appearance of clinical symptoms. To accomplish this objective, a novel heterocyclic molecule (4) was synthesized and validated as Aβ targeted probe. The agent shows labeling of numerous diffuse Aβ plaques in confirmed AD human brain tissues and traverses the blood-brain barrier to enable labeling of parenchymal Aβ plaques in live mice (APP(±)/PS1(±)) brains.