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声脉冲对微球的捕获:脉冲长度的影响。

Trapping of a mie sphere by acoustic pulses: effects of pulse length.

作者信息

Kang Shih-Tsung, Yeh Chih-Kuang

出版信息

IEEE Trans Ultrason Ferroelectr Freq Control. 2013 Jul;60(7):1487-97. doi: 10.1109/TUFFC.2013.2721.

DOI:10.1109/TUFFC.2013.2721
PMID:25004516
Abstract

The acoustic counterpart of optical tweezers shows great promise as a single-particle manipulator using a highly focused acoustic beam. Understanding the dependence of the trapping performance of the acoustic beam on the acoustic pulse length may facilitate its development and extend the applications. Herein, we propose a ray-based model for the time-course simulation of instantaneous forces exerted on single Mie spheres by highly focused acoustic pulses of arbitrary lengths. The simulations considered single fat/lipid spheres with a density of 950 kg/m3 and speed of sound of 1450 m/s, suspended in water and located on the beam axis. Simulation was used to establish the spatial and temporal pressure data of pulsed acoustic fields transmitted from a 100-MHz transducer with a half-power bandwidth of 50% and an f-number of 1. The instantaneous intensity vectors were calculated to represent rays for estimating forces exerted by consecutive wave-particle interactions. The results suggest that short acoustic pulses can exert negative forces pulling spheres beyond the focus in the direction opposite to that of wave propagation. Varying the excitation pulse duration has no effect on the region where the exerted forces are averagely negative. Lengthening the excitation pulse duration rapidly increases the amplitude of the average force. A smaller sphere experiences a greater average force when the spatial length of a transmitted acoustic pulse is comparable to the sphere diameter. The amplitude of the instantaneous force can be maximized as long as the acoustic pulse length is longer than the sphere diameter. Regulating the relation between acoustic pulse length and sphere size may be advantageous in particle sorting applications.

摘要

作为一种使用高度聚焦声束的单粒子操纵器,光镊的声学对应物显示出巨大的潜力。了解声束的捕获性能对声脉冲长度的依赖性可能有助于其发展并扩展应用范围。在此,我们提出了一种基于射线的模型,用于对任意长度的高度聚焦声脉冲施加在单个米氏球上的瞬时力进行时程模拟。模拟考虑了密度为950 kg/m³、声速为1450 m/s的单个脂肪/脂质球,该球悬浮在水中并位于声束轴上。模拟用于建立从具有50%半功率带宽和1的f数的100 MHz换能器发射的脉冲声场的空间和时间压力数据。计算瞬时强度矢量以表示射线,用于估计连续波 - 粒子相互作用施加的力。结果表明,短声脉冲可以施加负力,将球体拉到焦点之外,方向与波传播方向相反。改变激发脉冲持续时间对平均力为负的区域没有影响。延长激发脉冲持续时间会迅速增加平均力的幅度。当发射的声脉冲的空间长度与球体直径相当时,较小的球体受到的平均力更大。只要声脉冲长度大于球体直径,瞬时力的幅度就可以最大化。在粒子分选应用中,调节声脉冲长度与球体大小之间的关系可能是有利的。

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