Yu Yanyan, Qiu Weibao, Chiu Bernard, Sun Lei
Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China.
Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Sensors (Basel). 2015 Feb 27;15(3):4958-74. doi: 10.3390/s150304958.
Both optical tweezers and acoustic tweezers have been demonstrated for trapping small particles in diverse biomedical applications. Compared to the optical tweezers, acoustic tweezers have deeper penetration, lower intensity, and are more useful in light opaque media. These advantages enable the potential utility of acoustic tweezers in biological science. Since the first demonstration of acoustic tweezers, various applications have required the trapping of not only one, but more particles simultaneously in both the axial and lateral direction. In this research, a method is proposed to create multiple trapping patterns, to prove the feasibility of trapping micro-particles. It has potential ability to electronically control the location and movement of the particles in real-time. A multiple-focus acoustic field can be generated by controlling the excitation of the transducer elements. The pressure and intensity of the field are obtained by modeling phased array transducer. Moreover, scattering force and gradient force at various positions are also evaluated to analyze their relative components to the effect of the acoustic tweezers. Besides, the axial and lateral radiation force and the trapping trajectory are computed based on ray acoustic approach. The results obtained demonstrate that the acoustic tweezers are capable of multiple trapping in both the axial and lateral directions.
光镊和声镊都已被证明可用于各种生物医学应用中捕获小颗粒。与光镊相比，声镊具有更深的穿透力、更低的强度，并且在光不透明介质中更有用。这些优点使声镊在生物科学中具有潜在的应用价值。自从首次展示声镊以来，各种应用不仅需要在轴向和横向同时捕获一个颗粒，还需要捕获更多颗粒。在本研究中，提出了一种创建多个捕获模式的方法，以证明捕获微颗粒的可行性。它具有实时电子控制颗粒位置和运动的潜在能力。通过控制换能器元件的激励可以产生多焦点声场。通过对阵列换能器进行建模获得场的压力和强度。此外，还评估了不同位置的散射力和梯度力，以分析它们相对于声镊效应的相对分量。此外，基于射线声学方法计算轴向和横向辐射力以及捕获轨迹。获得的结果表明，声镊能够在轴向和横向进行多重捕获。
