Brinton E A, Eisenberg S, Breslow J L
Laboratory of Biochemical Genetics and Metabolism, Rockefeller University, New York 10021.
J Clin Invest. 1989 Jul;84(1):262-9. doi: 10.1172/JCI114149.
High levels of HDL-cholesterol (HDL-C) protect against coronary heart disease susceptibility, but the metabolic mechanisms underlying elevated HDL-C levels are poorly understood. We now report the turnover of isologous radioiodinated HDL apolipoproteins, apo A-I and apo A-II, in 15 female subjects on a metabolic diet with HDL-C levels ranging from 51 to 122 mg/dl. The metabolic parameters, fractional catabolic rate (FCR) and absolute synthetic rate (SR), were determined for apo A-I and apo A-II in all subjects. There was an inverse correlation between plasma HDL-C and the FCR of apo A-I and apo A-II (r = -0.75, P less than 0.001, and r = -0.54, P = 0.036, respectively), but no correlation with the SR of either apo A-I or apo A-II (r = 0.09, and r = -0.16, respectively, both P = NS). Apo A-I levels correlated inversely with apo A-I FCR (r = -0.64, P = 0.01) but not with apo A-I SR (r = 0.30, P = NS). In contrast, plasma levels of apo A-II did not correlate with apo A-II FCR (r = -0.38, P = 0.16), but did correlate with apo A-II SR (r = 0.65, P = 0.009). Further analysis showed that apo A-I and apo A-II FCR were inversely correlated with the HDL-C/apo A-I + A-II ratio (r = -0.69 and -0.61, P = 0.005 and 0.015, respectively). These data suggest that: (a) low HDL apolipoprotein FCR is the predominant metabolic mechanism of elevated HDL-C levels; (b) apo A-I FCR is the primary factor in controlling plasma apo A-I levels, but apo A-II SR is the primary factor controlling plasma apo A-II levels; (c) low HDL apolipoprotein FCR is associated with a lipid-rich HDL fraction. These findings elucidate aspects of HDL metabolism which contribute to high HDL-C levels and which may constitute mechanisms for protection against coronary heart disease.
高水平的高密度脂蛋白胆固醇（HDL-C）可预防冠心病易感性，但HDL-C水平升高背后的代谢机制却知之甚少。我们现在报告了15名女性受试者在代谢饮食下，同源放射性碘标记的HDL载脂蛋白apo A-I和apo A-II的周转率，这些受试者的HDL-C水平在51至122mg/dl之间。测定了所有受试者中apo A-I和apo A-II的代谢参数，即分数分解代谢率（FCR）和绝对合成率（SR）。血浆HDL-C与apo A-I和apo A-II的FCR呈负相关（分别为r = -0.75，P < 0.001和r = -0.54，P = 0.036），但与apo A-I或apo A-II的SR均无相关性（分别为r = 0.09和r = -0.16，P均为无统计学意义）。apo A-I水平与apo A-I FCR呈负相关（r = -0.64，P = 0.01），但与apo A-I SR无相关性（r = 0.30，P为无统计学意义）。相比之下，apo A-II的血浆水平与apo A-II FCR无相关性（r = -0.38，P = 0.16），但与apo A-II SR相关（r = 0.65，P = 0.009）。进一步分析表明，apo A-I和apo A-II FCR与HDL-C/apo A-I + A-II比值呈负相关（分别为r = -0.69和-0.61，P = 0.
