Plougastel Lucie, Koniev Oleksandr, Specklin Simon, Decuypere Elodie, Créminon Christophe, Buisson David-Alexandre, Wagner Alain, Kolodych Sergii, Taran Frédéric
CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, Gif sur Yvette, F-91191, France.
Chem Commun (Camb). 2014 Aug 25;50(66):9376-8. doi: 10.1039/c4cc03816a.
New sydnone derivatives have been synthesized and screened for their capacity to undergo fast copper-free cycloaddition reaction with bicyclo-[6.1.0]-nonyne. The influences of substitution in positions N-3 and C-4 of sydnones have been particularly studied leading to the identification of highly reactive partners for bio-orthogonal ligation reactions.
已合成了新型斯德酮衍生物，并对其与双环-[6.1.0]-壬炔进行快速无铜环加成反应的能力进行了筛选。特别研究了斯德酮N-3和C-4位取代的影响，从而确定了用于生物正交连接反应的高活性反应物。
