Laboratorio de Toxicología de Productos Naturales, Departamento de Farmacia, Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, Av. Wilfrido Massieu, Gustavo A. Madero, Ciudad de México 07738, Mexico.
Laboratorio de Investigación Biomédica en Productos Naturales, Carrera de Medicina, UNAM, FES-Iztacala, Avenida de los Barrios Número 1, Colonia Los Reyes Iztacala, Estado de México 54090, Mexico.
Nutrients. 2021 Sep 11;13(9):3169. doi: 10.3390/nu13093169.
Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people.
非甾体抗炎药（NSAIDs）导致的胃溃疡疾病是一个主要的公共卫生问题。用于治疗的疗法会给患者带来不良反应。蜂胶是一种天然产物，已在全球范围内用于治疗各种疾病。然而，关于蜂胶在 NSAIDs 治疗引起的胃溃疡中的活性的信息很少。因此，本综述评估并比较了蜂胶的胃保护潜力及其对 NSAID 诱导的胃溃疡的作用，为此在 PubMed 和 ScienceDirect 数据库中进行了系统搜索。主要标准是报告蜂胶对 NSAIDs 对胃黏膜损伤的胃保护活性的文章。胃保护与抗氧化、抗分泌和细胞保护作用有关，以及蜂胶化学成分中存在的酚类化合物。然而，大多数研究使用了不同剂量的 NSAIDs 和蜂胶，并评估了不同的参数。蜂胶已被证明是治疗胃溃疡疾病的良好选择。然而，应该进行未来的研究以确定负责这些作用的化合物，并确定它们在人群中的潜在用途。
