利用发育过程进行血管工程和再生。
Harnessing developmental processes for vascular engineering and regeneration.
机构信息
Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences-Oncology Center, and The Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.
Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences-Oncology Center, and The Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21208, USA
出版信息
Development. 2014 Jul;141(14):2760-9. doi: 10.1242/dev.102194.
The formation of vasculature is essential for tissue maintenance and regeneration. During development, the vasculature forms via the dual processes of vasculogenesis and angiogenesis, and is regulated at multiple levels: from transcriptional hierarchies and protein interactions to inputs from the extracellular environment. Understanding how vascular formation is coordinated in vivo can offer valuable insights into engineering approaches for therapeutic vascularization and angiogenesis, whether by creating new vasculature in vitro or by stimulating neovascularization in vivo. In this Review, we will discuss how the process of vascular development can be used to guide approaches to engineering vasculature. Specifically, we will focus on some of the recently reported approaches to stimulate therapeutic angiogenesis by recreating the embryonic vascular microenvironment using biomaterials for vascular engineering and regeneration.
血管的形成对于组织的维持和再生至关重要。在发育过程中，血管通过血管生成和血管生成这两个过程形成，并在多个水平上受到调节：从转录层次和蛋白质相互作用到来自细胞外环境的输入。了解血管形成如何在体内协调可以为治疗性血管生成和血管生成的工程方法提供有价值的见解，无论是通过在体外创建新的血管还是通过刺激体内的新血管生成。在这篇综述中，我们将讨论如何利用血管发育过程来指导工程血管的方法。具体来说，我们将重点介绍一些最近报道的方法，这些方法通过使用生物材料来进行血管工程和再生，从而重新创建胚胎血管微环境来刺激治疗性血管生成。
Zotero 插件