Jain Rakesh K
E.L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA.
Nat Med. 2003 Jun;9(6):685-93. doi: 10.1038/nm0603-685.
The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall for structural support and regulation of vessel function. In addition, the vascular network must be organized so that all the parenchymal cells receive adequate nutrients. All of these processes are orchestrated by physical forces as well as by a constellation of ligands and receptors whose spatio-temporal patterns of expression and concentration are tightly regulated. Inappropriate levels of these physical forces or molecules produce an abnormal vasculature--a hallmark of various pathologies. Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering.
由血管生成或血管新生形成的新生血管的成熟，需要募集壁细胞、生成细胞外基质以及使血管壁特化以提供结构支持并调节血管功能。此外，血管网络必须进行组织构建，以便所有实质细胞都能获得充足的营养。所有这些过程都由物理力以及一系列配体和受体精心调控，这些配体和受体的表达和浓度的时空模式受到严格调节。这些物理力或分子水平不当会产生异常血管——这是各种病理状态的一个标志。异常血管的正常化可促进药物向肿瘤的递送，而成熟血管的形成有助于实现治疗性血管生成和组织工程的前景。
