移动 DNA 元件在大脑多样性和复杂性的产生中的作用。
Mobile DNA elements in the generation of diversity and complexity in the brain.
机构信息
Salk Institute for Biological Studies, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
Nat Rev Neurosci. 2014 Aug;15(8):497-506. doi: 10.1038/nrn3730. Epub 2014 Jul 9.
Abstract
Mobile elements are DNA sequences that can change their position (retrotranspose) within the genome. Although its biological function is largely unappreciated, DNA derived from mobile elements comprises nearly half of the human genome. It has long been thought that neuronal genomes are invariable; however, recent studies have demonstrated that mobile elements actively retrotranspose during neurogenesis, thereby creating genomic diversity between neurons. In addition, mounting data demonstrate that mobile elements are misregulated in certain neurological disorders, including Rett syndrome and schizophrenia.
摘要
移动元件是可以在基因组内改变其位置（反向转录）的 DNA 序列。尽管其生物学功能在很大程度上尚未被理解，但源自移动元件的 DNA 占人类基因组的近一半。长期以来，人们一直认为神经元基因组是不变的；然而，最近的研究表明，移动元件在神经发生过程中积极反向转录，从而在神经元之间产生基因组多样性。此外，越来越多的证据表明，移动元件在某些神经障碍中失调，包括雷特综合征和精神分裂症。
相似文献
1
Mobile DNA elements in the generation of diversity and complexity in the brain.移动 DNA 元件在大脑多样性和复杂性的产生中的作用。
Nat Rev Neurosci. 2014 Aug;15(8):497-506. doi: 10.1038/nrn3730. Epub 2014 Jul 9.
2
LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?LINE-1 反转录转座子：神经元基因组体细胞变异的介体？
Trends Neurosci. 2010 Aug;33(8):345-54. doi: 10.1016/j.tins.2010.04.001. Epub 2010 May 12.
3
Mobile elements: drivers of genome evolution.移动元件：基因组进化的驱动因素
Science. 2004 Mar 12;303(5664):1626-32. doi: 10.1126/science.1089670.
4
Retroelement-derived RNA and its role in the brain.反转录元件衍生的 RNA 及其在大脑中的作用。
Semin Cell Dev Biol. 2021 Jun;114:68-80. doi: 10.1016/j.semcdb.2020.11.001. Epub 2020 Nov 21.
5
Transposable elements and human cancer: a causal relationship?转座元件与人类癌症：一种因果关系？
Biochim Biophys Acta. 2013 Jan;1835(1):28-35. doi: 10.1016/j.bbcan.2012.09.001. Epub 2012 Sep 12.
6
Mobile DNA Elements: The Seeds of Organic Complexity on Earth.移动DNA元件：地球上有机复杂性的种子
DNA Cell Biol. 2015 Oct;34(10):597-609. doi: 10.1089/dna.2015.2938. Epub 2015 Jul 29.
7
Increased l1 retrotransposition in the neuronal genome in schizophrenia.精神分裂症中神经元基因组 L1 逆转座子的增加。
Neuron. 2014 Jan 22;81(2):306-13. doi: 10.1016/j.neuron.2013.10.053. Epub 2014 Jan 2.
8
Mobile DNA in Old World monkeys: a glimpse through the rhesus macaque genome.旧世界猴中的可移动DNA：通过恒河猴基因组一窥究竟。
Science. 2007 Apr 13;316(5822):238-40. doi: 10.1126/science.1139462.
9
Study of Transposable Elements and Their Genomic Impact.转座元件及其基因组影响的研究。
Methods Mol Biol. 2016;1400:1-19. doi: 10.1007/978-1-4939-3372-3_1.
10
Mobile genetic elements as natural tools for genome evolution.作为基因组进化天然工具的可移动遗传元件
Methods Mol Biol. 2004;260:1-20. doi: 10.1385/1-59259-755-6:001.
引用本文的文献
1
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease.转座元件的转录和转录后调控及其在发育和疾病中的作用。
Nat Rev Mol Cell Biol. 2025 Jun 30. doi: 10.1038/s41580-025-00867-8.
2
Disruption of TAD hierarchy promotes LTR co-option in cancer.拓扑相关结构域（TAD）层级的破坏促进了癌症中长末端重复序列（LTR）的借用。
Nat Genet. 2025 Jun 30. doi: 10.1038/s41588-025-02239-6.
3
Sequence Diversity and Encoded Enzymatic Differences of Monocistronic L1 ORF2 mRNA Variants in the Aged Normal and Alzheimer's Disease Brain.老年正常大脑和阿尔茨海默病大脑中单核细胞L1 ORF2 mRNA变体的序列多样性和编码酶差异
J Neurosci. 2025 Jun 18;45(25):e2298242025. doi: 10.1523/JNEUROSCI.2298-24.2025.
4
KRAB zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution.KRAB锌指蛋白调节内源性逆转录病毒以塑造生殖系转录组和基因组进化。
Genome Res. 2025 Mar 12;35(3):417-31. doi: 10.1101/gr.279924.124.
5
Retrotransposons and the brain: Exploring a complex relationship between mobile elements, stress, and neurological health.逆转录转座子与大脑：探索移动元件、应激和神经健康之间的复杂关系。
Neurobiol Stress. 2025 Jan 18;34:100709. doi: 10.1016/j.ynstr.2025.100709. eCollection 2025 Jan.
6
Repetitive element transcript accumulation is associated with inflammaging in humans.重复元件转录本积累与人类的炎症衰老有关。
Geroscience. 2024 Dec;46(6):5663-5679. doi: 10.1007/s11357-024-01126-y. Epub 2024 Apr 20.
7
Causes and Consequences of Varying Transposable Element Activity: An Evolutionary Perspective.转座元件活性变化的原因及其后果：一种进化角度的分析。
Annu Rev Genomics Hum Genet. 2024 Aug;25(1):1-25. doi: 10.1146/annurev-genom-120822-105708. Epub 2024 Aug 6.
8
Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation.长散在核元件可防止神经祖细胞过早分化。
Cell Rep. 2024 Feb 27;43(2):113774. doi: 10.1016/j.celrep.2024.113774. Epub 2024 Feb 13.
9
Transposable element insertions in 1000 Swedish individuals.1000 名瑞典个体中的转座元件插入。
PLoS One. 2023 Jul 28;18(7):e0289346. doi: 10.1371/journal.pone.0289346. eCollection 2023.
10
Evolutionarily recent retrotransposons contribute to schizophrenia.进化上较新的反转录转座子与精神分裂症有关。
Transl Psychiatry. 2023 May 27;13(1):181. doi: 10.1038/s41398-023-02472-9.
本文引用的文献
1
Increased l1 retrotransposition in the neuronal genome in schizophrenia.精神分裂症中神经元基因组 L1 逆转座子的增加。
Neuron. 2014 Jan 22;81(2):306-13. doi: 10.1016/j.neuron.2013.10.053. Epub 2014 Jan 2.
2
Epigenetic control of gene expression in the alcoholic brain.酒精性脑病中基因表达的表观遗传调控
Alcohol Res. 2013;35(1):69-76.
3
RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells.RNAi 依赖性和非依赖性控制小鼠胚胎干细胞中 LINE1 的积累和迁移。
PLoS Genet. 2013 Nov;9(11):e1003791. doi: 10.1371/journal.pgen.1003791. Epub 2013 Nov 7.
4
The role of transposable elements in health and diseases of the central nervous system.转座元件在中枢神经系统的健康和疾病中的作用。
J Neurosci. 2013 Nov 6;33(45):17577-86. doi: 10.1523/JNEUROSCI.3369-13.2013.
5
Mosaic copy number variation in human neurons.人类神经元中的镶嵌拷贝数变异。
Science. 2013 Nov 1;342(6158):632-7. doi: 10.1126/science.1243472.
6
Differential L1 regulation in pluripotent stem cells of humans and apes.人源和猿源多能干细胞中的 L1 调控差异。
Nature. 2013 Nov 28;503(7477):525-529. doi: 10.1038/nature12686. Epub 2013 Oct 23.
7
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons.人胚胎干细胞衍生的瑞特综合征神经元中的全局转录和翻译抑制
Cell Stem Cell. 2013 Oct 3;13(4):446-58. doi: 10.1016/j.stem.2013.09.001.
8
The Microprocessor controls the activity of mammalian retrotransposons.微处理器控制哺乳动物反转录转座子的活性。
Nat Struct Mol Biol. 2013 Oct;20(10):1173-81. doi: 10.1038/nsmb.2658. Epub 2013 Sep 1.
9
Rates and patterns of great ape retrotransposition.巨猿反转录转座率及模式。
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13457-62. doi: 10.1073/pnas.1310914110. Epub 2013 Jul 24.
10
Activation of transposable elements during aging and neuronal decline in Drosophila.果蝇衰老和神经元衰退过程中转座元件的激活。
Nat Neurosci. 2013 May;16(5):529-31. doi: 10.1038/nn.3368. Epub 2013 Apr 7.
Zotero 插件