抗癫痫药物治疗神经病理性疼痛和纤维肌痛。
Antiepileptic drugs for neuropathic pain and fibromyalgia.
机构信息
Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
Department of Anaesthesia, Intensive Care Medicine, Emergency Medicine, and Pain Medicine, Helsinki University Central Hospital, Helsinki, Finland3Institute of Clinical Medicine, University of Helsinki, Finland.
出版信息
JAMA. 2014 Jul;312(2):182-3. doi: 10.1001/jama.2014.6336.
CLINICAL QUESTION
Are antiepileptic drugs associated with reduced pain intensity in patients with neuropathic pain or fibromyalgia?
BOTTOM LINE
In treating diabetic neuropathy and postherpetic neuralgia compared with placebo, gabapentin and pregabalin are associated with a modest increase in the number of patients experiencing meaningful pain reduction. In treating fibromyalgia, compared with placebo, pregabalin alone is associated with a small increase in the number of patients experiencing meaningful pain reduction. There is insufficient evidence for other antiepileptics.
临床问题
抗癫痫药物是否会降低神经痛或纤维肌痛患者的疼痛强度？
结论
与安慰剂相比，加巴喷丁和普瑞巴林治疗糖尿病性周围神经病变和带状疱疹后神经痛时，可使更多患者的疼痛得到有意义的减轻；普瑞巴林单独治疗纤维肌痛时，与安慰剂相比，可使更多患者的疼痛得到有意义的减轻。其他抗癫痫药物的证据不足。
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