维生素 D 补充对糖尿病患者神经病变特异性生活质量的改善。
Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation.
机构信息
Department of Eye and Vision Sciences, Institute of Ageing and Chronic Disease, University of Liverpool and Aintree University Hospital NHS Foundation Trust, Liverpool, UK.
Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, University of Manchester, Manchester, UK.
出版信息
J Diabetes Res. 2017;2017:7928083. doi: 10.1155/2017/7928083. Epub 2017 Dec 28.
OBJECTIVE
To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy.
METHODS
This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks.
RESULTS
Of 143 participants, 41.3% were vitamin D deficient (vitamin D < 20 ng/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D ( < 0.0001) and a significant improvement in the NeuroQoL subscale score for emotional distress ( = 0.04), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of "quite a lot" ( < 0.05) and "very much" ( < 0.0001) with a significant reduction in the baseline response of having a "poor" QoL from 5.2% to 0.7% ( < 0.0001) and an increase in the response of an "excellent QoL" from 1.5% to 7.4% ( < 0.0001).
CONCLUSION
Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.
目的
评估维生素 D 补充对痛性糖尿病周围神经病变患者周围神经病变特异性生活质量（NeuroQoL）的影响。
方法
这是一项前瞻性、开放标签研究，于 2012 年 6 月至 2013 年 4 月进行。给予有症状的糖尿病周围神经病变患者单次 600,000IU 肌内维生素 D，在基线和每 4 周一次的 5 次随访时评估 NeuroQoL。
结果
在 143 名参与者中，41.3%为维生素 D 缺乏症（维生素 D < 20ng/ml）。维生素 D 治疗导致 25(OH)D 显著增加（<0.0001），情绪困扰的 NeuroQoL 亚量表评分显著改善（=0.04），而疼痛症状和感觉异常、温度和触觉丧失、不稳定性、日常活动受限和人际问题等其他 NeuroQoL 领域无显著变化。患者对足部问题的生活质量认知有显著改善，“相当多”（<0.05）和“非常多”（<0.0001）的比例显著降低，基线时“较差”生活质量的比例从 5.2%降至 0.7%（<0.0001），“极好”生活质量的比例从 1.5%升至 7.4%（<0.0001）。
结论
维生素 D 可有效改善痛性糖尿病周围神经病变患者的生活质量。
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