Valley Anesthesiology and Pain Consultants, Envision Physician Services, 645 E. Missouri Avenue, Suite 300, Phoenix, AZ, 85012, USA.
Department of Anesthesiology, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
Curr Pain Headache Rep. 2019 May 1;23(6):37. doi: 10.1007/s11916-019-0774-0.
Neuropathic pain is often debilitating, severely limiting the daily lives of patients who are affected. Typically, neuropathic pain is difficult to manage and, as a result, leads to progression into a chronic condition that is, in many instances, refractory to medical management.
Gabapentinoids, belonging to the calcium channel blocking class of drugs, have shown good efficacy in the management of chronic pain and are thus commonly utilized as first-line therapy. Various sodium channel blocking drugs, belonging to the categories of anticonvulsants and local anesthetics, have demonstrated varying degrees of efficacy in the in the treatment of neurogenic pain. Though there is limited medical literature as to efficacy of any one drug, individualized multimodal therapy can provide significant analgesia to patients with chronic neuropathic pain.
神经性疼痛常使人虚弱，严重限制受影响患者的日常生活。通常，神经性疼痛难以控制，因此导致其发展为慢性疾病，在许多情况下，对医学治疗具有抗性。
加巴喷丁类药物属于钙通道阻滞剂类药物，在慢性疼痛管理方面显示出良好的疗效，因此通常被用作一线治疗药物。各种钠离子通道阻滞剂药物，属于抗惊厥药和局部麻醉药类别，在治疗神经源性疼痛方面显示出不同程度的疗效。虽然关于任何一种药物的疗效的医学文献有限，但个体化的多模式治疗可以为慢性神经性疼痛患者提供显著的镇痛效果。
