Bell K J, Gray R, Munns D, Petocz P, Howard G, Colagiuri S, Brand-Miller J C
Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, School of Molecular Bioscience, The University of Sydney, Sydney, NSW, Australia.
Sydney Insulin Pump Clinic, Sydney, NSW, Australia.
Eur J Clin Nutr. 2014 Sep;68(9):1055-9. doi: 10.1038/ejcn.2014.126. Epub 2014 Jul 9.
BACKGROUND/OBJECTIVE: The Food Insulin Index (FII) is a novel algorithm for ranking foods on the basis of insulin responses in healthy subjects relative to an isoenergetic reference food. Our aim was to compare postprandial glycemic responses in adults with type 1 diabetes who used both carbohydrate counting and the FII algorithm to estimate the insulin dosage for a variety of protein-containing foods.
SUBJECTS/METHODS: A total of 11 adults on insulin pump therapy consumed six individual foods (steak, battered fish, poached eggs, low-fat yoghurt, baked beans and peanuts) on two occasions in random order, with the insulin dose determined once by the FII algorithm and once with carbohydrate counting. Postprandial glycemia was measured in capillary blood glucose samples at 15-30 min intervals over 3 h. Researchers and participants were blinded to treatment.
Compared with carbohydrate counting, the FII algorithm significantly reduced the mean blood glucose level (5.7±0.2 vs 6.5±0.2 mmol/l, P=0.003) and the mean change in blood glucose level (-0.7±0.2 vs 0.1±0.2 mmol/l, P=0.001). Peak blood glucose was reached earlier using the FII algorithm than using carbohydrate counting (34±5 vs 56±7 min, P=0.007). The risk of hypoglycemia was similar in both treatments (48% vs 33% for FII vs carbohydrate counting, respectively, P=0.155).
In adults with type 1 diabetes, compared with carbohydrate counting, the novel FII algorithm improved postprandial hyperglycemia after consumption of protein-containing foods.
背景/目的：食物胰岛素指数（FII）是一种全新的算法，用于根据健康受试者相对于等能量参考食物的胰岛素反应对食物进行排名。我们的目的是比较1型糖尿病成年患者在使用碳水化合物计数法和FII算法来估算各种含蛋白质食物的胰岛素剂量时的餐后血糖反应。
受试者/方法：共有11名接受胰岛素泵治疗的成年人分两次随机食用六种单一食物（牛排、裹面糊炸鱼、水煮蛋、低脂酸奶、烘豆和花生），胰岛素剂量一次通过FII算法确定，一次通过碳水化合物计数法确定。在3小时内每隔15 - 30分钟采集毛细血管血葡萄糖样本以测量餐后血糖。研究人员和参与者对治疗方法不知情。
与碳水化合物计数法相比，FII算法显著降低了平均血糖水平（5.7±0.2 vs 6.5±0.2 mmol/l，P = 0.003）以及血糖水平的平均变化值（-0.7±0.2 vs 0.1±0.2 mmol/l，P = 0.001）。使用FII算法比使用碳水化合物计数法更早达到血糖峰值（34±5 vs 56±7分钟，P = 0.007）。两种治疗方法中低血糖风险相似（FII组和碳水化合物计数法组分别为48%和33%，P = 0.155）。
在1型糖尿病成年患者中，与碳水化合物计数法相比，新型FII算法在食用含蛋白质食物后改善了餐后高血糖情况。
