Klokkevold P R, Miller D A, Friedlander A H
Section of Hospital Dentistry, University of California at Los Angeles, School of Dentistry and Medical Center.
Oral Surg Oral Med Oral Pathol. 1989 Jun;67(6):689-93. doi: 10.1016/0030-4220(89)90010-8.
The uncontrolled production of immunoglobulins in Waldenström's macroglobulinemia, a neoplastic plasma cell disorder, results in hyperviscosity of blood and multisystem organ derangement. Previously reported orofacial manifestations have been limited to osteolytic lesions of the jaw, ulcerations of the mucosa and tongue, gingival bleeding, and enlargement of salivary and lacrimal glands. Mental nerve anesthesia resulting from IgM deposition on the myelin sheath is a previously unreported early warning sign of advancing disease. Its occurrence heralds the need for aggressive medical management.
华氏巨球蛋白血症是一种肿瘤性浆细胞疾病，免疫球蛋白的失控产生会导致血液高黏滞性和多系统器官紊乱。先前报道的口面部表现仅限于颌骨溶骨性病变、黏膜和舌部溃疡、牙龈出血以及唾液腺和泪腺肿大。IgM沉积于髓鞘导致的颏神经麻醉是疾病进展的一个先前未报道的早期预警信号。它的出现预示着需要积极的药物治疗。
