These authors contributed equally to this work.
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Pulm Circ. 2013 Dec;3(4):959-62. doi: 10.1086/674820.
Malignant melanoma is the most aggressive form of skin cancer and carries a predisposition for metastasis to many different organs. Pulmonary dissemination is common, most often presenting as multiple discrete pulmonary nodules. While a variety of other intrathoracic patterns can occur, diffuse parenchymal infiltration causing acute respiratory failure is an extremely rare manifestation of metastatic disease. We present a case of an otherwise healthy man who developed rapidly progressive respiratory failure mimicking acute respiratory distress syndrome due to melanomatous infiltration of the lung parenchyma and airways.
恶性黑色素瘤是最具侵袭性的皮肤癌，易转移至许多不同的器官。肺转移很常见，最常表现为多个离散的肺结节。虽然可能出现多种其他类型的胸腔内表现，但弥漫性实质浸润导致急性呼吸衰竭是转移性疾病的一种极其罕见的表现。我们报告了一例原本健康的男性患者，由于肺实质和气道的黑色素瘤浸润，迅速发展为呼吸衰竭，类似于急性呼吸窘迫综合征。
