Hanamornroongruang Suchanan, Sangchay Napakorn
Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Oncol Lett. 2013 Apr;5(4):1250-1252. doi: 10.3892/ol.2013.1165. Epub 2013 Jan 30.
Diffuse parenchymal metastasis is an unusual pattern of liver metastasis that is capable of causing liver failure. In the present study, the authors describe malignant infiltration of the liver by primary breast carcinoma in an autopsy of a 49-year-old female who had a rapid onset of liver failure and died after three weeks. Ultrasonography and computed tomography (CT) scans of the abdomen, as well as macroscopic examination, failed to detect liver metastasis; while microscopic examination revealed diffuse tumor cells with a loss of E-cadherin expression infiltrating into the liver parenchyma. The prognosis of liver failure associated with malignant infiltration is extremely poor; the survival time of patients is extremely low. Liver biopsy may be the most efficient technique for confirming the diagnosis during the patient's life.
弥漫性实质转移是一种不常见的肝转移模式，可导致肝衰竭。在本研究中，作者描述了一名49岁女性尸检时原发性乳腺癌对肝脏的恶性浸润，该患者肝衰竭起病迅速，三周后死亡。腹部超声和计算机断层扫描（CT）以及宏观检查均未检测到肝转移；而显微镜检查发现弥漫性肿瘤细胞，E-钙黏蛋白表达缺失，浸润至肝实质。与恶性浸润相关的肝衰竭预后极差；患者的生存时间极短。肝活检可能是在患者生前确诊的最有效技术。
