表观遗传学修饰：基本机制及其在心血管疾病中的作用（2013 年 Grover 会议系列）。
Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series).
机构信息
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Pulm Circ. 2014 Jun;4(2):169-74. doi: 10.1086/675979.
Abstract
Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunities for novel strategies for disease prevention and treatment.
摘要
表观遗传学是指可遗传的表型特征，这些特征不是 DNA 序列的结果。有三类表观遗传调控：DNA 甲基化、组蛋白修饰和非编码 RNA 作用。在心血管系统中，表观遗传调控影响发育、分化以及疾病易感性或表达。确定表观遗传调控的决定因素为疾病的预防和治疗提供了新的策略机会。
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