Matzen L E, Kvetny J, Pedersen K K
Department of Clinical Chemistry, Odense University Hospital, Denmark.
Scand J Clin Lab Invest. 1989 May;49(3):249-53.
The specific nuclear-binding of T3 (NBT3) in mononuclear blood cells, and the concentrations of TSH, thyroid hormones, and binding proteins were measured after overnight fasting in 12 obese and in 14 non-obese women, none of the subjects were taking any medicine. The concentrations of TSH and free plus bound-T3 (TT3) were significantly higher in the obese (p less than 0.05), concentrations of T4 and binding proteins did not differ. The NBT3 was significantly lower in the obese women; the maximal binding capacity (MBC) was 34.5 +/- 11.6 fmol/mg DNA in the obese subjects and 50.0 +/- 11.6 fmol/mg DNA in the non-obese subjects (p less than 0.02). The binding affinities did not differ. We have previously shown that increasing T3 concentrations within the physiological range down-regulates NBT3. Therefore, the reduced NBT3 in the obese women was probably secondary to the increased TT3 concentration and was not caused by a primary tissue resistance. The higher TSH and TT3 in the obese women could be caused by a greater caloric intake.
对12名肥胖女性和14名非肥胖女性在空腹过夜后，测量了她们单核血细胞中T3的特异性核结合（NBT3）以及促甲状腺激素（TSH）、甲状腺激素和结合蛋白的浓度，这些受试者均未服用任何药物。肥胖女性的TSH浓度以及游离T3与结合T3之和（TT3）浓度显著更高（p<0.05），T4和结合蛋白的浓度无差异。肥胖女性的NBT3显著更低；肥胖受试者的最大结合能力（MBC）为34.5±11.6 fmol/mg DNA，非肥胖受试者为50.0±11.6 fmol/mg DNA（p<0.02）。结合亲和力无差异。我们之前已经表明，在生理范围内增加T3浓度会下调NBT3。因此，肥胖女性中NBT3降低可能继发于TT3浓度升高，而非由原发性组织抵抗所致。肥胖女性中较高的TSH和TT3可能是由于热量摄入增加引起的。
