Kvetny J, Matzen L E, Blichert-Toft M, Watt-Boolsen S, Date J
Department of Clinical Chemistry, Odense University Hospital, Denmark.
Horm Metab Res. 1989 Mar;21(3):142-4. doi: 10.1055/s-2007-1009174.
Nuclear thyroxine and triiodothyronine receptor-binding in human mononuclear blood cells were examined in 14 euthyroid persons prior to and 1, 6, 24 and 53 weeks after goitre resection. One week after resection decreased serum T3 from 1.47 nmol/l to 1.14 nmol/l (P less than 0.05), FT4I from 103 a. u. to 94 a. u. and SHBG from 80 nmol/l to 69 nmol/l (P less than 0.05) followed after 6 weeks by a rise in serum TSH from 1.2 mU/l to 11.0 mU/l (P less than 0.05) suggesting an initial slight hypothyroidism. Nuclear receptor-binding of T4 and T3 increased within one week and eventually decreased to preresectional values. We conclude that the expected alteration of the metabolic state caused by resection of the gland is opposed by increased nuclear binding of T4 and T3.
对14名甲状腺功能正常者在甲状腺肿切除术前以及术后1周、6周、24周和53周时，检测其外周血单个核细胞中的甲状腺素及三碘甲状腺原氨酸核受体结合情况。术后1周，血清T3从1.47nmol/L降至1.14nmol/L（P<0.05），FT4I从103a.u.降至94a.u.，SHBG从80nmol/L降至69nmol/L（P<0.05），6周后血清TSH从1.2mU/L升至11.0mU/L（P<0.05），提示初期有轻度甲状腺功能减退。T4和T3的核受体结合在1周内增加，最终降至术前水平。我们得出结论，甲状腺切除所致代谢状态的预期改变被T4和T3核结合增加所抵消。
