Savcheniuk O A, Virchenko O V, Falalieieva T M, Beregova T V, Babenko L P, Lazarenko L M, Spivak M Ia
Fiziol Zh (1994). 2014;60(2):63-9.
The effect of a mixture of probiotic strains (2:1:1 Lactobacillus casei IMVB-7280, Bifidobacterium animalis VKL, Bifidobacterium animalis VKB) on the development of experimental obesity in rats induced by neonatal administration of monosodium glutamate has been studied. It was shown that in rats of 4 months age, the injection of monosodium glutamate (4 mg/g) at 2, 4, 6, 8, 10 days after birth elicited abdominal obesity and metabolic syndrome. An intermittent administration of a probiotic mixture to rats treated with monosodium prevented the development of obesity. In the group of rats treated with probiotics, anthropometric parameters (weight and body length, Lee index, body mass index) did not differ from the level of intact rats. Visceral fat mass was decreased by probiotics by 38.5% (P < 0.05) compared to rats treated with water. Probiotics improved lipid metabolism: reduced the level of VLDL by 32.2% (P < 0,05), the level of LDL by 30.6% (P < 0.05), increased HDL by 25.7% (P <0,05) compared to obese control rats. Probiotic strains restored the secretion of adipocytes hormones (leptin and adiponectin) to the normal level of intact animals. The results show the effectiveness of probiotics for the prevention of obesity.
研究了益生菌菌株混合物（干酪乳杆菌IMVB - 7280、动物双歧杆菌VKL、动物双歧杆菌VKB，比例为2:1:1）对新生期注射谷氨酸钠诱导的大鼠实验性肥胖发展的影响。结果表明，在4个月龄的大鼠中，出生后第2、4、6、8、10天注射谷氨酸钠（4mg/g）会引发腹部肥胖和代谢综合征。对用谷氨酸钠处理的大鼠间歇性给予益生菌混合物可预防肥胖的发展。在用益生菌处理的大鼠组中，人体测量参数（体重、体长、李氏指数、体重指数）与未处理大鼠的水平无差异。与用水处理的大鼠相比，益生菌使内脏脂肪量减少了38.5%（P<0.05）。益生菌改善了脂质代谢：与肥胖对照大鼠相比，极低密度脂蛋白（VLDL）水平降低了32.2%（P<0.05），低密度脂蛋白（LDL）水平降低了30.6%（P<0.05），高密度脂蛋白（HDL）水平升高了25.7%（P<0.05）。益生菌菌株将脂肪细胞激素（瘦素和脂联素）的分泌恢复到未处理动物的正常水平。结果表明益生菌对预防肥胖有效。
