Takeda Ryosuke, Kawamura Akie, Kawashima Aki, Moriwaki Hiroki, Sato Tatsunori, Aceña José Luis, Soloshonok Vadim A
Hamari Chemicals Ltd, 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka, Japan 533-0024.
Org Biomol Chem. 2014 Aug 28;12(32):6239-49. doi: 10.1039/c4ob00669k. Epub 2014 Jul 10.
This work presents the first chemical approach for the resolution of α-amino acids offering the following advantages: (1) The specially designed resolving reagent is derived from α-(phenyl)ethylamine, the most inexpensive chiral auxiliary, which can be recycled and reused, rendering the cost structure of the complete process very attractive; (2) the time-efficient two-step process can be conducted under operationally convenient conditions with virtually quantitative yields; and (3) the process can readily be adapted to large-scale use.
这项工作提出了第一种用于拆分α-氨基酸的化学方法，具有以下优点：（1）特别设计的拆分试剂衍生自α-（苯基）乙胺，这是最便宜的手性助剂，可回收再利用，使整个过程的成本结构极具吸引力；（2）高效的两步法可在操作方便的条件下进行，产率几乎定量；（3）该方法可轻松适用于大规模应用。
