对映体 1-苯乙胺（α-PEA）的合成应用的新进展：手性诱导剂和辅助剂的优势。

New Advances in the Synthetic Application of Enantiomeric 1-Phenylethylamine (α-PEA): Privileged Chiral Inducer and Auxiliary.

机构信息

Chair of Organic and Medicinal Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland.

出版信息

Molecules. 2020 Oct 23;25(21):4907. doi: 10.3390/molecules25214907.

DOI:10.3390/molecules25214907

PMID:33114098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7660327/

Abstract

New developments in the synthesis, resolution, and synthetic applications of chiral 1-phenylethylamine (α-PEA) reported in the last decade have been reviewed. In particular, improvements in the synthesis of α-PEA and its derivatives and chiral resolution, as well as their applications in the resolution of other compounds, were discussed. α-PEA was used as a chiral auxiliary in the diastereoselective synthesis of medicinal substances and natural products. Chiral ligands with α-PEA moieties were applied in asymmetric reactions, and effective modular chiral organocatalysts were constructed with α-PEA fragments and used in important synthetic reactions.

摘要

过去十年中报道的手性 1-苯乙胺（α-PEA）的合成、拆分和合成应用的新进展进行了综述。特别是，讨论了 α-PEA 及其衍生物的合成改进和手性拆分，以及它们在手性拆分其他化合物中的应用。α-PEA 被用作手性助剂用于药物和天然产物的非对映选择性合成。带有 α-PEA 部分的手性配体被应用于不对称反应中，并且使用 α-PEA 片段构建了有效的模块化手性有机催化剂，并用于重要的合成反应中。