Sun Gongping, Tang Yuanxin, Li Xiaoxia, Meng Jin, Liang Gaofeng
Department of Gastrointestinal Surgery, The Fourth Affiliated Hospital of the China Medical University, No, 4 Chongshan Road, Shenyang 110032, China.
World J Surg Oncol. 2014 Jul 9;12:202. doi: 10.1186/1477-7819-12-202.
The purpose of this research was to evaluate the therapeutic effects and prognostic factors of transanal local excision (TAE) for rectal cancer.
We retrospectively analyzed 116 cases that underwent TAE for rectal cancer from 1995 to 2008. A Cox regression analysis was used to analyze prognostic factors.
The survival times for the patients were from 14 to 160.5 months (median time, 58.5 months). The 5-year and 10-year overall survival rates were 72% and 53%, respectively. In all 16 cases experienced local recurrence (13.8%). Pathological type, recurrence or metastasis, and depth of infiltration (T stage) were the prognostic factors according to the univariate analysis, and the latter two were independent factors affecting patient prognosis. For patients with T1 stage who underwent adjuvant radiotherapy, there was no local recurrence; for those in T2 stage, the local recurrence rate was 14.6%. In addition, there was no difference between the patients who received radiotherapy and those who did not (T1: P = 0.260, T2: P = 0.262 for survival rate and T1: P = 0.480, T2: P = 0.560 for recurrence).
The result of TAE for rectal cancer is satisfactory for T1 stage tumors, but it is not suitable for T2 stage tumors.
本研究旨在评估经肛门局部切除术（TAE）治疗直肠癌的疗效及预后因素。
我们回顾性分析了1995年至2008年间接受TAE治疗的116例直肠癌患者。采用Cox回归分析来分析预后因素。
患者的生存时间为14至160.5个月（中位时间为58.5个月）。5年和10年总生存率分别为72%和53%。16例患者均出现局部复发（13.8%）。单因素分析显示病理类型、复发或转移以及浸润深度（T分期）为预后因素，后两者是影响患者预后的独立因素。对于接受辅助放疗的T1期患者，无局部复发；T2期患者局部复发率为14.6%。此外，接受放疗和未接受放疗的患者之间无差异（T1：生存率P = 0.260，T2：P = 0.262；T1：复发P = 0.480，T2：P = 0.560）。
TAE治疗T1期直肠癌效果满意，但不适用于T2期肿瘤。
