Shin Dong Jin, Wang Tza-Huei
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Ann Biomed Eng. 2014 Nov;42(11):2289-302. doi: 10.1007/s10439-014-1060-2. Epub 2014 Jul 10.
This review summarizes recent developments in the use of magnetically actuated droplets in point-of-care molecular diagnostic platforms. We discuss the fundamentals of magnetic droplet manipulation and the various modes of actuation. The balance of forces acting on a droplet during transport and particle extraction, as well as the devices and instrumentation developed to perform these operations will be presented and discussed. Furthermore, we review some of the recent advances on the diagnostic applications of platforms utilizing magnetic manipulation for genetic assessment of biological samples.
本综述总结了磁驱动液滴在即时分子诊断平台中的应用的最新进展。我们讨论了磁液滴操控的基本原理和各种驱动模式。将介绍并讨论在液滴传输和颗粒提取过程中作用于液滴的力的平衡，以及为执行这些操作而开发的设备和仪器。此外，我们还综述了利用磁操控对生物样品进行基因评估的平台在诊断应用方面的一些最新进展。
