McSharry Brian P, Forbes Simone K, Cao John Z, Avdic Selmir, Machala Emily A, Gottlieb David J, Abendroth Allison, Slobedman Barry
Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Virus Research, Westmead Millennium Institute, Sydney, NSW, Australia.
J Virol. 2014 Sep;88(18):10990-4. doi: 10.1128/JVI.01259-14. Epub 2014 Jul 9.
Regulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMV in vivo. In vitro, Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction.
首次在人巨细胞病毒（HCMV）感染期间研究了凝集素半乳糖凝集素9（Gal-9）的调节情况。在体内HCMV重新激活的移植受者中，Gal-9转录显著上调。在体外，HCMV可独立于病毒基因表达强力上调Gal-9，其中干扰素β（IFN-β）被确定为这种效应的介质。本研究确定了一种因HCMV感染而强力增加的免疫调节蛋白，以及一种通过IFN-β诱导来控制Gal-9的新机制。
