Borresen Erica C, Gundlach Kerry A, Wdowik Melissa, Rao Sangeeta, Brown Regina J, Ryan Elizabeth P
Department of Environmental and Radiological Health Sciences.
Department of Food Science and Human Nutrition, Colorado State University, 1680 Campus Delivery, Fort Collins, CO 80523, USA.
Curr Nutr Food Sci. 2014 May;10(2):112-119. doi: 10.2174/1573401310666140306005934.
Emerging evidence supports that increased consumption of dry beans ( L.) reduces both the incidence and recurrence of adenomatous polyps or precancerous growths. Navy beans have been studied for dietary colorectal cancer (CRC) chemoprevention in animal models. Our main objectives were to assess the feasibility of increased navy bean consumption in adults with and without history of CRC and to achieve intake amounts associated with chemoprevention.
Seven meals and six snacks were developed for both the absence and inclusion of cooked navy bean powder (35grams/day). Sixteen healthy adults (7 non-cancer and 9 CRC survivors) completed the placebo-controlled, randomized, single-blinded dietary intervention trial. Participants consumed one study-provided meal and snack daily for 28 days, which accounted for approximately one-third of their total recommended caloric intake (meals = 202-483 kcal and snacks = 194-401 kcal). Participants also recorded three-day dietary food logs each week.
The addition of 35g of cooked navy bean powder (NBP) into foods provided 5-8% daily caloric intake. The compliance to the meal and snack intervention ranged from 89-100%. Non-cancer participants in the NBP group had a significant decrease in total caloric intake after week 4 (p≤0.0001). CRC survivors in the NBP group significantly increased total fiber intake by week 4 (p≤0.0001).
NBP are feasible to include in meals for increased total fiber intake and for consuming the amount that is associated with CRC chemoprevention outcomes. These findings warrant further evaluation of NBP consumption in clinical nutrition trials for CRC control and prevention.
新出现的证据支持，增加干豆（L.）的摄入量可降低腺瘤性息肉或癌前病变的发生率和复发率。海军豆已在动物模型中进行了饮食性结直肠癌（CRC）化学预防的研究。我们的主要目标是评估在有或无CRC病史的成年人中增加海军豆摄入量的可行性，并达到与化学预防相关的摄入量。
针对是否添加煮熟的海军豆粉（35克/天），分别设计了七餐和六种零食。16名健康成年人（7名非癌症患者和9名CRC幸存者）完成了安慰剂对照、随机、单盲饮食干预试验。参与者每天食用一份研究提供的餐食和零食，持续28天，这约占他们推荐总热量摄入的三分之一（餐食=202-483千卡，零食=194-401千卡）。参与者还每周记录三天的饮食日志。
在食物中添加35克煮熟的海军豆粉（NBP）提供了5-8%的每日热量摄入。餐食和零食干预的依从性范围为89-100%。NBP组的非癌症参与者在第4周后总热量摄入显著下降（p≤0.0001）。NBP组的CRC幸存者在第4周时总纤维摄入量显著增加（p≤0.0001）。
NBP可 feasibly 纳入餐食中，以增加总纤维摄入量，并达到与CRC化学预防结果相关的摄入量。这些发现值得在CRC控制和预防的临床营养试验中对NBP的摄入量进行进一步评估。 （注：feasibly 原词有误，根据语境推测这里可能是“feasible”，翻译为“可行地” ）
