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拓展视野:把握大脑复杂性。

Enlarging the scope: grasping brain complexity.

机构信息

The Human Brain and Behavior Laboratory, Center for Complex Systems and Brain Sciences, Florida Atlantic University Boca Raton, FL, USA.

The Human Brain and Behavior Laboratory, Center for Complex Systems and Brain Sciences, Florida Atlantic University Boca Raton, FL, USA ; Intelligent System Research Centre, University of Ulster Derry, Northern Ireland.

出版信息

Front Syst Neurosci. 2014 Jun 25;8:122. doi: 10.3389/fnsys.2014.00122. eCollection 2014.

DOI:10.3389/fnsys.2014.00122
PMID:25009476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4070173/
Abstract

To further advance our understanding of the brain, new concepts and theories are needed. In particular, the ability of the brain to create information flows must be reconciled with its propensity for synchronization and mass action. The theoretical and empirical framework of Coordination Dynamics, a key aspect of which is metastability, are presented as a starting point to study the interplay of integrative and segregative tendencies that are expressed in space and time during the normal course of brain and behavioral function. Some recent shifts in perspective are emphasized, that may ultimately lead to a better understanding of brain complexity.

摘要

为了进一步深入了解大脑,我们需要新的概念和理论。特别是,大脑产生信息流的能力必须与它同步和大规模活动的倾向相协调。协调动力学的理论和经验框架,其中一个关键方面是亚稳性,被提出作为研究在大脑和行为功能的正常过程中,在空间和时间上表达的整合和分离倾向相互作用的起点。本文强调了一些最近的观点转变,这些转变可能最终有助于更好地理解大脑的复杂性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1b/4070173/9d8cb0bb043b/fnsys-08-00122-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1b/4070173/2678521cb12b/fnsys-08-00122-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1b/4070173/9d8cb0bb043b/fnsys-08-00122-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1b/4070173/2678521cb12b/fnsys-08-00122-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c1b/4070173/9d8cb0bb043b/fnsys-08-00122-g0002.jpg

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本文引用的文献

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The metastable brain.亚稳态大脑。
Neuron. 2014 Jan 8;81(1):35-48. doi: 10.1016/j.neuron.2013.12.022.
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Biophysically based computational models of astrocyte ~ neuron coupling and their functional significance.基于生物物理学的星形胶质细胞-神经元耦合计算模型及其功能意义。
Front Comput Neurosci. 2013 May 7;7:44. doi: 10.3389/fncom.2013.00044. eCollection 2013.
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Metastability and inter-band frequency modulation in networks of oscillating spiking neuron populations.振荡尖峰神经元群体网络中的亚稳性和带间频率调制。
协调动力学:理解社会行为的基础。
Front Hum Neurosci. 2020 Aug 14;14:317. doi: 10.3389/fnhum.2020.00317. eCollection 2020.
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Metastable neural dynamics underlies cognitive performance across multiple behavioural paradigms.亚稳态神经动力学是多种行为范式下认知表现的基础。
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Connectomics of Morphogenetically Engineered Neurons as a Predictor of Functional Integration in the Ischemic Brain.形态发生工程改造神经元的连接组学作为缺血性脑功能整合的预测指标
Front Neurol. 2019 Jun 12;10:630. doi: 10.3389/fneur.2019.00630. eCollection 2019.
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Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome.阿尔茨海默病中不稳定的神经动力学是由结构连接组的病变破坏的。
Neuroimage. 2018 Dec;183:438-455. doi: 10.1016/j.neuroimage.2018.08.033. Epub 2018 Aug 18.
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The Temporal Propagation of Intrinsic Brain Activity Associate With the Occurrence of PTSD.与创伤后应激障碍发生相关的大脑内在活动的时间传播。
Front Psychiatry. 2018 May 25;9:218. doi: 10.3389/fpsyt.2018.00218. eCollection 2018.
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Outline of a general theory of behavior and brain coordination.行为与大脑协调的一般理论纲要。
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Beyond the blank slate: routes to learning new coordination patterns depend on the intrinsic dynamics of the learner-experimental evidence and theoretical model.超越白板:学习新协调模式的途径取决于学习者的内在动力学——实验证据与理论模型。
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Multistability and metastability: understanding dynamic coordination in the brain.多稳定性和亚稳定性:理解大脑中的动态协调。
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