Department of General Physiology, St. Petersburg State University St. Petersburg, Russia.
Department of Veterinary Medicine, Institute of Veterinary Physiology, Freie Universität Berlin Berlin, Germany.
Front Physiol. 2014 Jun 24;5:221. doi: 10.3389/fphys.2014.00221. eCollection 2014.
Pleura consists of visceral and parietal cell layers, producing a fluid, which is necessary for lubrication of the pleural space. Function of both mesothelial cell layers is necessary for the regulation of a constant pleural fluid volume and composition to facilitate lung movement during breathing. Recent studies have demonstrated that pleural mesothelial cells show a distinct expression pattern of tight junction proteins which are known to ubiquitously determine paracellular permeability. Most tight junction proteins provide a sealing function to epithelia, but some have been shown to have a paracellular channel function or ambiguous properties. Here we provide an in-depth review of the current knowledge concerning specific functional contribution of these proteins determining transport and barrier function of pleural mesothelium.
胸膜由内脏层和壁层细胞组成，产生一种液体，这对于胸膜腔的润滑是必要的。两层间皮细胞的功能对于调节恒定的胸膜液体积和组成以促进呼吸时的肺运动是必要的。最近的研究表明，胸膜间皮细胞表现出紧密连接蛋白的独特表达模式，这些蛋白被广泛认为决定了细胞旁通透性。大多数紧密连接蛋白为上皮细胞提供密封功能，但有些已被证明具有细胞旁通道功能或模糊的特性。在这里，我们深入回顾了关于这些蛋白决定胸膜间皮运输和屏障功能的特定功能贡献的现有知识。
