后皮质萎缩向皮质基底节综合征的进展：神经退行性疾病是合并还是区分？
The progression of posterior cortical atrophy to corticobasal syndrome: lumping or splitting neurodegenerative diseases?
作者信息
Giorelli Maurizio, Losignore Nunzia Alessandra, Bagnoli Junia, Difazio Pasquale, Zimatore Giovanni Bosco
机构信息
Operative Unit of Neurology, "Dimiccoli" General Hospital, Barletta, Italy.
Operative Unit of Nuclear Medicine, "Dimiccoli" General Hospital, Barletta, Italy.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2014 Jun 24;4:244. doi: 10.7916/D81G0JCQ. eCollection 2014.
BACKGROUND
Posterior cortical atrophy is a clinical syndrome that is characterized by the progressive loss of visuospatial integration and is associated with neurodegenerative conditions.
CASE REPORT
We describe a 60-year-old female with simultanagnosia, oculomotor apraxia, and optic ataxia for which she received an initial clinical diagnosis of posterior cortical atrophy. Three years later, she developed Balint's syndrome, Gerstmann's syndrome, left alien hand syndrome, smooth asymmetric (left) rigidity, cortical sensory loss, and spontaneous myoclonic jerks of the left arm, which suggested a final diagnosis of corticobasal syndrome.
DISCUSSION
This case report indicates that corticobasal syndrome may present with visuospatial deficits.
背景
后皮质萎缩是一种临床综合征，其特征为视空间整合功能进行性丧失，并与神经退行性疾病相关。
病例报告
我们描述了一名60岁女性，她患有同时失认症、眼球运动失用症和视觉性共济失调，最初临床诊断为后皮质萎缩。三年后，她出现了巴林特综合征、格斯特曼综合征、左侧异己手综合征、平滑不对称（左侧）僵硬、皮质感觉丧失以及左臂自发性肌阵挛性抽搐，最终诊断为皮质基底节综合征。
讨论
本病例报告表明皮质基底节综合征可能表现为视空间缺陷。
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