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后皮质萎缩向皮质基底节综合征的进展:神经退行性疾病是合并还是区分?

The progression of posterior cortical atrophy to corticobasal syndrome: lumping or splitting neurodegenerative diseases?

作者信息

Giorelli Maurizio, Losignore Nunzia Alessandra, Bagnoli Junia, Difazio Pasquale, Zimatore Giovanni Bosco

机构信息

Operative Unit of Neurology, "Dimiccoli" General Hospital, Barletta, Italy.

Operative Unit of Nuclear Medicine, "Dimiccoli" General Hospital, Barletta, Italy.

出版信息

Tremor Other Hyperkinet Mov (N Y). 2014 Jun 24;4:244. doi: 10.7916/D81G0JCQ. eCollection 2014.

DOI:10.7916/D81G0JCQ
PMID:25009764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4069812/
Abstract

BACKGROUND

Posterior cortical atrophy is a clinical syndrome that is characterized by the progressive loss of visuospatial integration and is associated with neurodegenerative conditions.

CASE REPORT

We describe a 60-year-old female with simultanagnosia, oculomotor apraxia, and optic ataxia for which she received an initial clinical diagnosis of posterior cortical atrophy. Three years later, she developed Balint's syndrome, Gerstmann's syndrome, left alien hand syndrome, smooth asymmetric (left) rigidity, cortical sensory loss, and spontaneous myoclonic jerks of the left arm, which suggested a final diagnosis of corticobasal syndrome.

DISCUSSION

This case report indicates that corticobasal syndrome may present with visuospatial deficits.

摘要

背景

后皮质萎缩是一种临床综合征,其特征为视空间整合功能进行性丧失,并与神经退行性疾病相关。

病例报告

我们描述了一名60岁女性,她患有同时失认症、眼球运动失用症和视觉性共济失调,最初临床诊断为后皮质萎缩。三年后,她出现了巴林特综合征、格斯特曼综合征、左侧异己手综合征、平滑不对称(左侧)僵硬、皮质感觉丧失以及左臂自发性肌阵挛性抽搐,最终诊断为皮质基底节综合征。

讨论

本病例报告表明皮质基底节综合征可能表现为视空间缺陷。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d2/4069812/ae08ea6e2d67/tre-04-244-5629-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d2/4069812/ae08ea6e2d67/tre-04-244-5629-1-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d2/4069812/ae08ea6e2d67/tre-04-244-5629-1-g001.jpg

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本文引用的文献

1
Criteria for the diagnosis of corticobasal degeneration.皮质基底节变性的诊断标准。
Neurology. 2013 Jan 29;80(5):496-503. doi: 10.1212/WNL.0b013e31827f0fd1.
2
Posterior cortical atrophy.后部皮质萎缩。
Lancet Neurol. 2012 Feb;11(2):170-8. doi: 10.1016/S1474-4422(11)70289-7.
3
The multiple phenotypes of corticobasal syndrome and corticobasal degeneration: implications for further study.皮质基底节综合征和皮质基底节变性的多种表型:对进一步研究的影响。
后皮质萎缩的运动特征及其影像学关联
Neurobiol Aging. 2014 Dec;35(12):2845-2857. doi: 10.1016/j.neurobiolaging.2014.05.028. Epub 2014 Jun 6.
J Mol Neurosci. 2011 Nov;45(3):350-3. doi: 10.1007/s12031-011-9624-1. Epub 2011 Aug 19.
4
The neuropathology of probable Alzheimer disease and mild cognitive impairment.可能的阿尔茨海默病和轻度认知障碍的神经病理学
Ann Neurol. 2009 Aug;66(2):200-8. doi: 10.1002/ana.21706.
5
Is the pathology of corticobasal syndrome predictable in life?皮质基底节综合征的病理学在生前是否可预测?
Mov Disord. 2009 Aug 15;24(11):1593-9. doi: 10.1002/mds.22558.
6
Cognitive phenotypes in Alzheimer's disease and genetic risk.阿尔茨海默病的认知表型与遗传风险
Cortex. 2007 Oct;43(7):835-45. doi: 10.1016/s0010-9452(08)70683-x.
7
What are we seeing? Is posterior cortical atrophy just Alzheimer disease?我们看到了什么?后部皮质萎缩仅仅是阿尔茨海默病吗?
Neurology. 2006 Feb 14;66(3):300-1. doi: 10.1212/01.wnl.0000202093.81603.d8.
8
Progressive posterior cortical dysfunction: a clinicopathologic series.进行性后皮质功能障碍:一项临床病理系列研究
Neurology. 2004 Oct 12;63(7):1175-80. doi: 10.1212/01.wnl.0000140290.80962.bf.
9
Pathologically confirmed corticobasal degeneration presenting with visuospatial dysfunction.经病理证实的皮质基底节变性伴视觉空间功能障碍。
Neurology. 2003 Oct 28;61(8):1134-5. doi: 10.1212/01.wnl.0000086814.35352.b3.
10
Corticobasal ganglionic degeneration with Balint's syndrome.伴有巴林特综合征的皮质基底节变性
J Neuropsychiatry Clin Neurosci. 2000 Spring;12(2):273-5. doi: 10.1176/jnp.12.2.273.