1] Institut Paoli-Calmettes, UMR912, Marseille, France [2] INSERM, UMR912, Economics and Social Sciences Applied to Health & Analysis of Medical Information (SESSTIM), Marseille, France [3] Aix-Marseille University, UMR_S912, IRD, Marseille, France.
1] INSERM, UMR912, Economics and Social Sciences Applied to Health & Analysis of Medical Information (SESSTIM), Marseille, France [2] Aix-Marseille University, UMR_S912, IRD, Marseille, France.
Genet Med. 2015 Feb;17(2):117-24. doi: 10.1038/gim.2014.82. Epub 2014 Jul 10.
This study aimed to measure patients' smoking patterns for 5 years after BRCA1/2 test result disclosure.
A national cohort consisting of 621 French cancer-free women from families with BRCA1/2 mutations (mean age (SD): 40.5 years (11.5 years)) were included from December 1999 to January 2006, before disclosure of genetic test results, and followed for 5 years. They completed self-administered questionnaires about their cigarette smoking behaviors before receiving their test results (baseline) and 6, 12, 24, and 60 months after disclosure. Multivariate statistical analyses of the changes in participants' smoking behaviors were performed using a zero-inflated Poisson mixed model.
Baseline smoking was found to depend on age, educational level, marital status, alcohol consumption, body mass index, and cancer risk perception. The zero-inflated part of the model showed the occurrence of no significant changes in the percentage of smokers during the 5 years after disclosure of the BRCA1/2 test results; however, daily smoking among BRCA1/2 carriers decreased significantly compared with that of noncarriers (adjusted hazard ratio = 0.83; (95% confidence interval: 0.69-0.99); P = 0.04) after adjusting for baseline smoking behavior.
It would be worth investigating the possibility of counseling women during the genetic testing process about the multiple risk factors involved in cancer, such as genetic and lifestyle factors.
本研究旨在测量 BRCA1/2 检测结果披露后 5 年内患者的吸烟模式。
本研究纳入了一个由 621 名来自携带 BRCA1/2 突变家族的无癌法国女性组成的全国队列（平均年龄（标准差）：40.5 岁（11.5 岁）），研究时间为 1999 年 12 月至 2006 年 1 月，在基因检测结果披露之前，并随访 5 年。她们在接受检测结果之前（基线）和披露后 6、12、24 和 60 个月时，完成了关于吸烟行为的自我报告问卷。使用零膨胀泊松混合模型对参与者吸烟行为的变化进行了多变量统计分析。
基线吸烟与年龄、教育程度、婚姻状况、饮酒量、体重指数和癌症风险感知有关。模型的零膨胀部分显示，BRCA1/2 检测结果披露后 5 年内吸烟者的比例没有显著变化；然而，与非携带者相比，BRCA1/2 携带者的日吸烟量显著下降（调整后的危险比=0.83；95%置信区间：0.69-0.99；P=0.04），调整了基线吸烟行为。
在基因检测过程中，对女性进行有关癌症的多种风险因素（如遗传和生活方式因素）的咨询是值得探讨的。
