Institute of Cellular Medicine, Newcastle University, UK.
Institute of Health and Society, Newcastle University, UK.
J Hepatol. 2014 Nov;61(5):1158-65. doi: 10.1016/j.jhep.2014.06.034. Epub 2014 Jul 7.
Cirrhosis has a long natural history with considerable symptomatic impacts, particularly in advancing disease. Measuring health related quality of life (HRQOL) in liver disease provides detail about the nature and extent of its effects on individuals. Understanding the drivers of impaired HRQOL can help identify targets for improvement through new treatments or health systems service delivery. Evaluation of novel therapies which target symptomatic improvement, should be done with suitable outcome measures, including HRQOL assessment. In this article, we provide an overview of HRQOL in advanced liver disease for the clinician. A clear description of the important HRQOL tools is given alongside a discussion of the factors, which are known to contribute to impaired HRQOL in advanced liver disease.
肝硬化具有很长的自然病史，会对患者产生显著的症状影响，尤其是在疾病进展期。在肝病中测量健康相关生活质量（HRQOL）可详细了解其对个体的影响的性质和程度。了解导致 HRQOL 受损的因素有助于通过新的治疗方法或卫生系统服务提供来确定改善目标。对于旨在改善症状的新型疗法的评估，应使用合适的结局测量指标，包括 HRQOL 评估。在本文中，我们为临床医生提供了晚期肝病患者 HRQOL 的概述。本文还提供了重要的 HRQOL 工具的清晰描述，并讨论了已知会导致晚期肝病中 HRQOL 受损的因素。
