Sun Cui-Cui, Qu Xian-Jun, Gao Zu-Hua
aDepartment of Pharmacology, Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Shandong University, Jinan bDepartment of Pharmacology, School of Chemical Biology and Pharmaceutical Sciences cDepartment of Pathology, Beijing You An Hospital, Capital Medical University, Beijing, China dDepartment of Pathology, McGill University, Montreal, Quebec, Canada.
Anticancer Drugs. 2014 Nov;25(10):1107-21. doi: 10.1097/CAD.0000000000000145.
Integrins are a large family of cell surface receptors that bind extracellular matrix proteins. The interaction of integrins with extracellular matrix activates a number of intracellular signaling pathways involved in cell proliferation, differentiation, motility, and other essential cell functions. Integrins are critically important to both health and disease. In this review, we first describe the structure, functions, and signaling characteristics of integrins. We then discuss the roles of integrins in cancer progression. Finally, we recapitulate the laboratory and clinical efforts of targeting integrins as effective means of cancer therapy and diagnosis. This comprehensive review could help scientists and clinicians gain a complete understanding of integrins. It could also contribute toward the development of new drugs, new methods of diagnostics, and new treatment of cancers to benefit the patients in clinical practice.
整合素是一大类细胞表面受体，可与细胞外基质蛋白结合。整合素与细胞外基质的相互作用激活了许多参与细胞增殖、分化、运动及其他重要细胞功能的细胞内信号通路。整合素对健康和疾病都至关重要。在本综述中，我们首先描述整合素的结构、功能和信号特征。然后讨论整合素在癌症进展中的作用。最后，我们总结了将整合素作为癌症治疗和诊断的有效手段的实验室和临床研究成果。这一全面综述有助于科学家和临床医生全面了解整合素。它还可能有助于开发新药、新诊断方法和癌症新疗法，从而在临床实践中使患者受益。
