整合素在肿瘤发生发展中的作用及其靶向抑制剂。

Roles of integrin in tumor development and the target inhibitors.

机构信息

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.

出版信息

Chin J Nat Med. 2019 Apr;17(4):241-251. doi: 10.1016/S1875-5364(19)30028-7.

DOI:10.1016/S1875-5364(19)30028-7

PMID:31076128

Abstract

Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.

摘要

整合素是一大类细胞黏附分子（CAMs），参与细胞/细胞和细胞/细胞外基质（ECM）的相互作用，从而介导细胞增殖、分化、黏附、迁移等。近年来，在许多肿瘤研究中都明确发现整合素的异常表达，表明整合素与肿瘤的发生发展密切相关。同时，它对肿瘤细胞分化、细胞迁移、增殖和肿瘤新生血管生成有影响。针对整合素的药物研究对肿瘤的临床治疗具有重要意义。由于整合素在肿瘤发生和发展中的重要作用，整合素已成为癌症治疗的一个有前途的靶点。本文综述了整合素在肿瘤发生发展中的作用以及整合素抑制剂的研究现状，为后续研究提供有价值的参考。