Di Battista Ashley, Godfrey Celia, Soo Cheryl, Catroppa Cathy, Anderson Vicki
School of Behavioural Science, University of Melbourne, Melbourne, Australia; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Clinical Sciences, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
PLoS One. 2014 Jul 10;9(7):e101842. doi: 10.1371/journal.pone.0101842. eCollection 2014.
Traumatic brain injury is (TBI) a leading cause of morbidity and mortality in youth. Adult survivors of a severe pediatric TBI are vulnerable to global impairments, including greater employment difficulties, poor quality of life (HRQoL) and increased risk of mental health problems. When estimating the health related quality of life in adolescents, the presence of anxiety and depression and the quality of social relationships are important considerations, because adolescents are entrenched in social development during this phase of maturation. The influence of anxiety, depression and loneliness on health related quality of life in adolescent survivors of TBI has not been documented. This pilot study aimed to identify and measure the relationship between anxiety, depression and loneliness and perceived health related quality of life in adolescent survivors of a TBI.
mixed method/cohort pilot study (11 adolescents, mild to severe TBI; 9 parents), using self-report and proxy-report measures of anxiety, depression, health related quality of life, loneliness and clinical psychiatric interviews (adolescent only).
Self-reported depression was significantly correlated with self-reported HRQoL (rs [11] = -0.88, p<0.001). Age at injury was significantly correlated with self-reported HRQoL (rs [11] = -0.68, p = 0.02). Self-reported depression predicted self-reported HRQoL (R2 = 0.79, F [1, 10] = 33.48, p<0.001), but age at injury did not (R2 = 0.19, F [1, 10] = 2.09, p = 0.18).
Our results suggest that depression is a predictor of health related quality of life in youth post-TBI. The possibility of using targeted assessment and therapy for depression post-TBI to improve health related quality of life should be explored.
创伤性脑损伤（TBI）是青少年发病和死亡的主要原因。重度儿童TBI的成年幸存者易受全面损伤影响，包括就业困难加剧、生活质量差（健康相关生活质量[HRQoL]）以及心理健康问题风险增加。在评估青少年的健康相关生活质量时，焦虑和抑郁的存在以及社会关系质量是重要考量因素，因为青少年在此成熟阶段正处于社会发展的关键时期。焦虑、抑郁和孤独对TBI青少年幸存者健康相关生活质量的影响尚无文献记载。这项试点研究旨在识别并测量焦虑、抑郁和孤独与TBI青少年幸存者感知到的健康相关生活质量之间的关系。
混合方法/队列试点研究（11名青少年，轻度至重度TBI；9名家长），采用焦虑、抑郁、健康相关生活质量、孤独的自我报告和代理报告测量方法以及临床精神科访谈（仅针对青少年）。
自我报告的抑郁与自我报告的HRQoL显著相关（rs[11]= -0.88，p<0.001）。受伤时的年龄与自我报告的HRQoL显著相关（rs[11]= -0.68，p = 0.02）。自我报告的抑郁可预测自我报告的HRQoL（R2 = 0.79，F[1, 10]= 33.48，p<0.001），但受伤时的年龄则不能（R2 = 0.19，F[1, 10]= 2.09，p = 0.18）。
我们的结果表明，抑郁是TBI后青少年健康相关生活质量的一个预测因素。应探索对TBI后抑郁进行有针对性评估和治疗以改善健康相关生活质量的可能性。
