Department of Neuroscience, The School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Adv Neurobiol. 2024;42:205-218. doi: 10.1007/978-3-031-69832-3_10.
While our understanding of long-term disability after traumatic brain injury (TBI) has habitually focused on cognitive and sensorimotor functioning, it is increasingly appreciated that changes in social function for survivors of a brain injury are common and have a profound impact on one's quality of life. In this chapter, we highlight the consequences of TBI on social behavior, taking into account evidence from studies of patient populations as well as from preclinical animal models. After first considering the protracted nature of the development of social behavior across the lifespan, including the neurobiological networks that underlie social functioning, we discuss how TBI results in social behavior impairments and how these manifest. We focus particularly on how age-at-injury influences TBI-induced social impairments, with most of the evidence suggesting age-dependent vulnerability after injury at a younger age. In addition, we explore how biological sex is a key determinant of social behavior impairments after TBI, while gender in humans may also influence the nature and extent of social outcomes. Finally, we identify key knowledge gaps and emphasize the need for further research in the field.
虽然我们对创伤性脑损伤 (TBI) 后长期残疾的理解通常集中在认知和感觉运动功能上，但越来越多的人认识到，脑损伤幸存者的社会功能变化很常见，对他们的生活质量有深远影响。在本章中，我们将重点介绍 TBI 对社会行为的影响，同时考虑来自患者群体研究和临床前动物模型的证据。在首先考虑社会行为在整个生命周期中的发展的长期性，包括社交功能的神经生物学网络之后，我们讨论了 TBI 如何导致社会行为障碍以及这些障碍是如何表现出来的。我们特别关注年龄在损伤时如何影响 TBI 引起的社会障碍，大多数证据表明，在年轻时受伤后存在年龄依赖性的脆弱性。此外，我们还探讨了生物性别如何成为 TBI 后社会行为障碍的关键决定因素，而人类的性别也可能影响社会结果的性质和程度。最后，我们确定了关键的知识空白，并强调了该领域进一步研究的必要性。
