诺氟沙星治疗单纯性淋菌性尿道炎的临床试验：初步报告。
Clinical trial of norfloxacin in the treatment of uncomplicated gonococcal urethritis: preliminary report.
作者信息
Cristiano P
机构信息
Institute of Internal Medicine, 1st Medical School, Naples University, Italy.
出版信息
Drugs Exp Clin Res. 1989;15(1):33-5.
Fifteen male outpatients with uncomplicated gonococcal urethritis were treated by a single oral dose of norfloxacin (800 mg). Fourteen patients completely recovered from infection and a recurrence was noted in only one. Five of the Neisseria gonorrhoeae isolated (33.3%) were penicillin-resistant. However, the extremely low MICs confirm that norfloxacin possesses high antibacterial activity against N. gonorrhoeae. Norfloxacin was well tolerated with only a transient nausea occurring in four patients.
15名患有单纯性淋菌性尿道炎的男性门诊患者接受了单次口服800毫克诺氟沙星的治疗。14名患者感染完全康复，仅1名患者复发。分离出的淋病奈瑟菌中有5株（33.3%）对青霉素耐药。然而，极低的最低抑菌浓度证实诺氟沙星对淋病奈瑟菌具有高抗菌活性。诺氟沙星耐受性良好，只有4名患者出现短暂恶心。
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