多聚磷酸盐：止血领域的新角色。
Polyphosphate: a new player in the field of hemostasis.
作者信息
Smith Stephanie A, Morrissey James H
机构信息
Biochemistry Department, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
出版信息
Curr Opin Hematol. 2014 Sep;21(5):388-94. doi: 10.1097/MOH.0000000000000069.
Abstract
PURPOSE OF REVIEW
Polyphosphate (polyP) is an inorganic polymer that has recently been shown to be secreted by activated platelets. It is a potent modulator of the blood clotting and complement systems in hemostasis, thrombosis, and inflammation.
RECENT FINDINGS
This review focuses on what is currently known about which blood cells secrete polyP, and the roles that polyP plays in modulating the blood clotting and complement systems in health and disease.
SUMMARY
PolyP is a novel player in normal hemostasis and likely plays roles in thrombotic diseases and also in host responses to pathogens. It is also potentially a drug target, as its contributions to hemostasis appear to be to accelerate blood clotting but are not required for blood clotting to happen.
摘要
综述目的
多聚磷酸盐（polyP）是一种无机聚合物，最近研究表明其可由活化血小板分泌。它是止血、血栓形成和炎症过程中血液凝固和补体系统的强效调节剂。
最新发现
本综述聚焦于目前已知哪些血细胞分泌多聚磷酸盐，以及多聚磷酸盐在健康和疾病状态下调节血液凝固和补体系统中所起的作用。
总结
多聚磷酸盐是正常止血过程中的一个新角色，可能在血栓性疾病以及宿主对病原体的反应中发挥作用。它还有可能成为药物靶点，因为其对止血的作用似乎是加速血液凝固，但血液凝固的发生并不需要它。
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