Qi Mei-Ling, Xi Jing, Chen Li-Juan, Su Yi, Cen Yu-Ling, Su Feng-Xi, Lin Ying, Zhuang Zhi-Xiong, Tang Lu-Ying, Ren Ze-Fang
aSchool of Public Health bThe Third Affiliated Hospital cThe Second Affiliated Hospital dThe First Affiliated Hospital, Sun Yat-sen University, Guangzhou eShenzhen Center for Disease Control and Prevention, Shenzhen, China.
Eur J Cancer Prev. 2014 Sep;23(5):405-11. doi: 10.1097/CEJ.0000000000000071.
Reactivation of Epstein-Barr virus (EBV), as indexed by the higher immunoglobulin A (IgA) antibody titers, was reported to be associated with an increased risk of breast cancer. Passive smoking plays a role in host immune responses and may modify the association of EBV with breast cancer. We carried out a case-control study using data from 349 incident breast cancer cases and 500 age-matched controls in the Guangzhou Breast Cancer Study to investigate the interactions of EBV antibodies and passive smoking on breast cancer risk. A higher risk of breast cancer was observed in passive smokers who were seropositive for EBV viral capsid antigen IgA or nuclear antigen-1 IgA in serum compared with those with the seronegativity and no passive smoking [odds ratio 3.13 (95% confidence interval, 1.76-5.56)]. There was a significant linear trend for the risk of breast cancer from IgA seropositivity with passive smoking, only IgA seropositivity, only passive smoking, to seronegativity without passive smoking (P<0.001), but the interaction in either multiplicative or additive models was not significant. No significant association was found between passive smoking and EBV IgA seropositivity. The present study confirmed the associations of EBV IgA antibodies and passive smoking with the risk of breast cancer and suggested that there was no synergic action between passive smoking and EBV IgA seropositivity on the risk of breast cancer.
据报道，以较高的免疫球蛋白A（IgA）抗体滴度为指标的爱泼斯坦-巴尔病毒（EBV）再激活与乳腺癌风险增加有关。被动吸烟在宿主免疫反应中起作用，可能会改变EBV与乳腺癌之间的关联。我们利用广州乳腺癌研究中349例新发乳腺癌病例和500例年龄匹配对照的数据进行了一项病例对照研究，以调查EBV抗体和被动吸烟对乳腺癌风险的相互作用。与血清学阴性且无被动吸烟的人相比，血清中EBV病毒衣壳抗原IgA或核抗原-1 IgA呈血清阳性的被动吸烟者患乳腺癌的风险更高[比值比3.13（95%置信区间，1.76 - 5.56）]。从IgA血清阳性伴被动吸烟、仅IgA血清阳性、仅被动吸烟到血清学阴性且无被动吸烟，乳腺癌风险存在显著的线性趋势（P<0.001），但在乘法或加法模型中的相互作用不显著。未发现被动吸烟与EBV IgA血清阳性之间存在显著关联。本研究证实了EBV IgA抗体和被动吸烟与乳腺癌风险的关联，并表明被动吸烟与EBV IgA血清阳性在乳腺癌风险上不存在协同作用。
