The School of Public Health, Sun Yat-sen University, Guangzhou, China.
J Infect Dis. 2012 Jan 1;205(1):64-71. doi: 10.1093/infdis/jir710. Epub 2011 Nov 17.
The relationship between Epstein-Barr virus (EBV) and breast cancer (BC) is controversial. Interleukin-10 (IL-10) and interferon-γ (IFN-γ) are believed to play a critical role in the host's responses to EBV infection, and their genetic variations may modify the association of EBV with BC risk.
We examined serum levels of EBV viral capsid antigen (VCA) immunoglobulin A (IgA) and nuclear antigen-1 (EBNA-1) IgA along with the polymorphisms of IL-10 rs1800871 and IFN-γ rs2069705 in 354 incident BC cases and 504 age-matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression.
VCA IgA and EBNA-1 IgA levels were positively associated with BC risk. IL-10 rs1800871 (TC/CC) was associated with a reduced BC risk (OR, 0.74 [95% CI, 0.55-1.00]) but had no interaction with EBV infection on BC risk. IFN-γ rs2069705 was not directly associated with BC risk but interacted with EBNA-1 IgA on BC risk. Among women with the CC genotype, EBNA-1 IgA seropositivity significantly increased the risk of BC compared to EBNA-1 IgA seronegativity (OR, 5.14 [95% CI, 1.76-14.98]).
These results suggest that EBV may contribute to the risk of BC and that this contribution may be modified by genetic variations in IFN-γ.
EB 病毒（EBV）与乳腺癌（BC）之间的关系存在争议。白细胞介素 10（IL-10）和干扰素-γ（IFN-γ）被认为在宿主对 EBV 感染的反应中发挥关键作用，其遗传变异可能会改变 EBV 与 BC 风险的关联。
我们检测了 354 例新发 BC 病例和 504 例年龄匹配对照者的 EBV 衣壳抗原（VCA）免疫球蛋白 A（IgA）和核抗原-1（EBNA-1）IgA 血清水平，以及 IL-10 rs1800871 和 IFN-γ rs2069705 多态性。使用多变量 logistic 回归计算比值比（OR）和 95%置信区间（CI）。
VCA IgA 和 EBNA-1 IgA 水平与 BC 风险呈正相关。IL-10 rs1800871（TC/CC）与 BC 风险降低相关（OR，0.74 [95% CI，0.55-1.00]），但与 EBV 感染对 BC 风险无交互作用。IFN-γ rs2069705 与 BC 风险无直接关联，但与 EBNA-1 IgA 对 BC 风险有交互作用。在 CC 基因型女性中，EBNA-1 IgA 阳性者与 EBNA-1 IgA 阴性者相比，BC 风险显著增加（OR，5.14 [95% CI，1.76-14.98]）。
这些结果表明 EBV 可能有助于 BC 的发生，并且这种作用可能受到 IFN-γ 遗传变异的修饰。
