Wiener H L, Hashim A, Lajtha A, Sershen H
Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, Ward's Island, NY 10035.
Eur J Pharmacol. 1989 Apr 12;163(1):191-4. doi: 10.1016/0014-2999(89)90418-4.
L-Deprenyl is an inhibitor of monoamine oxidase B and dopamine uptake. Chronic L-deprenyl (10 mg/kg i.p., twice weekly for 4 weeks) was shown to inhibit monoamine oxidase B activity by 89%, and also to induce an up-regulation of the [3H]mazindol binding site associated with the striatal dopamine uptake carrier. Scatchard analysis indicated a 56% increase in the maximal number of [3H]mazindol binding sites in chronic L-deprenyl animals, but no effect on the affinity of these binding sites. The ability of L-deprenyl to up-regulate the [3H]mazindol-associated dopamine uptake carrier appears to be a result of its role as a dopamine uptake inhibitor.
左旋司来吉兰是单胺氧化酶B和多巴胺摄取的抑制剂。慢性给予左旋司来吉兰（腹腔注射10毫克/千克，每周两次，共4周）可使单胺氧化酶B活性抑制89%，还可诱导与纹状体多巴胺摄取载体相关的[3H]麦角吲哚结合位点上调。斯卡查德分析表明，慢性给予左旋司来吉兰的动物中，[3H]麦角吲哚结合位点的最大数量增加了56%，但对这些结合位点的亲和力没有影响。左旋司来吉兰上调[3H]麦角吲哚相关多巴胺摄取载体的能力似乎是其作为多巴胺摄取抑制剂作用的结果。
