• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多巴胺活性药物长期治疗后[3H]GBR - 12935结合未改变。

Unaltered [3H]GBR-12935 binding after chronic treatment with dopamine active drugs.

作者信息

Allard P, Eriksson K, Ross S B, Marcusson J O

机构信息

Department of Psychiatry, University of Umeå, Sweden.

出版信息

Psychopharmacology (Berl). 1990;102(3):291-4. doi: 10.1007/BF02244092.

DOI:10.1007/BF02244092
PMID:1979175
Abstract

Rats were injected intraperitoneally with haloperidol 0.5 mg/kg, raclopride 1 mg/kg, bromocriptine 2.5 mg/kg, d-amphetamine 2.5 mg/kg, or cocaine 10 mg/kg twice daily for 21 days. The animals were sacrificed 72 h after last injection. Control rats were injected with saline, following the same schedule. The radioligand [3H]GBR-12935 was used as a presynaptic marker for dopamine neurites. There were no significant differences in [3H]GBR-12935 binding to striatum between drug-treated rats and controls.

摘要

大鼠每天腹腔注射两次以下药物，持续21天：氟哌啶醇0.5毫克/千克、雷氯必利1毫克/千克、溴隐亭2.5毫克/千克、右旋苯丙胺2.5毫克/千克或可卡因10毫克/千克。在最后一次注射后72小时处死动物。按照相同的时间表给对照大鼠注射生理盐水。放射性配体[3H]GBR - 12935用作多巴胺神经突的突触前标记物。药物处理组大鼠和对照组大鼠的纹状体对[3H]GBR - 12935的结合没有显著差异。

相似文献

1
Unaltered [3H]GBR-12935 binding after chronic treatment with dopamine active drugs.多巴胺活性药物长期治疗后[3H]GBR - 12935结合未改变。
Psychopharmacology (Berl). 1990;102(3):291-4. doi: 10.1007/BF02244092.
2
[3H]GBR-12935 binding to dopamine uptake sites in rat striatum.[3H]GBR - 12935与大鼠纹状体中多巴胺摄取位点的结合。
Neuropsychobiology. 1990;23(4):177-81. doi: 10.1159/000119449.
3
Chronic haloperidol alters dopamine receptors: effects of cocaine exposure during the preweaning period.慢性氟哌啶醇会改变多巴胺受体：断奶前期接触可卡因的影响。
Eur J Pharmacol. 1999 Apr 16;370(3):241-9. doi: 10.1016/s0014-2999(99)00110-7.
4
Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration.可卡因对多巴胺转运体受体的影响取决于慢性可卡因给药途径。
Neuropsychopharmacology. 1996 Mar;14(3):205-10. doi: 10.1016/0893-133X(95)00090-Z.
5
Comparison of [3H]YM-09151-2 with [3H]spiperone and [3H]raclopride for dopamine d-2 receptor binding to rat striatum.
Eur J Pharmacol. 1989 Dec 7;173(2-3):177-82. doi: 10.1016/0014-2999(89)90516-5.
6
Quantitative autoradiography of the dopamine uptake complex in rat brain using [3H]GBR 12935: binding characteristics.使用[3H]GBR 12935对大鼠脑内多巴胺摄取复合物进行定量放射自显影：结合特性
Brain Res. 1991 Feb 1;540(1-2):1-13. doi: 10.1016/0006-8993(91)90486-f.
7
The role of D1 and D2 dopamine receptors in oral stereotypy induced by dopaminergic stimulation of the ventrolateral striatum.D1和D2多巴胺受体在腹外侧纹状体多巴胺能刺激诱导的口腔刻板行为中的作用。
Neuroscience. 1990;39(1):59-67. doi: 10.1016/0306-4522(90)90221-o.
8
The dopamine D2 antagonist remoxipride acts in vivo on a subpopulation of dopamine D2 receptors.多巴胺D2拮抗剂瑞莫必利在体内作用于多巴胺D2受体的一个亚群。
Neuroscience. 1994 Jul;61(2):269-83. doi: 10.1016/0306-4522(94)90230-5.
9
Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain.用瑞莫必利对大鼠进行亚慢性治疗未能改变大脑中的σ结合位点。
Eur J Pharmacol. 1992 Jun 5;226(2):157-61. doi: 10.1016/0922-4106(92)90177-w.
10
Alterations in the dopaminergic receptor system after chronic administration of cocaine.长期使用可卡因后多巴胺能受体系统的改变。
Synapse. 1993 Aug;14(4):314-23. doi: 10.1002/syn.890140409.

引用本文的文献

1
Classic Studies on the Interaction of Cocaine and the Dopamine Transporter.可卡因与多巴胺转运体相互作用的经典研究。
Clin Psychopharmacol Neurosci. 2015 Dec 31;13(3):227-38. doi: 10.9758/cpn.2015.13.3.227.
2
Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys.恒河猴因自我给药可卡因导致多巴胺转运体结合位点密度的变化进程。
J Neurosci. 2001 Apr 15;21(8):2799-807. doi: 10.1523/JNEUROSCI.21-08-02799.2001.
3
Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims.

本文引用的文献

1
Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice.持续接触苯丙胺对小鼠脑多巴胺浓度和突触体摄取的长期影响。
Eur J Pharmacol. 1980 Aug 8;65(4):439-43. doi: 10.1016/0014-2999(80)90351-9.
2
Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine.反复给予甲基苯丙胺后，纹状体多巴胺的长期耗竭及多巴胺摄取位点的丧失。
Brain Res. 1980 Jan 6;181(1):151-60. doi: 10.1016/0006-8993(80)91265-2.
3
Sodium-sensitive cocaine binding to rat striatal membrane: possible relationship to dopamine uptake sites.
J Neural Transm (Vienna). 1997;104(11-12):1353-60. doi: 10.1007/BF01294736.
4
Regional differences in the effects of amphetamine withdrawal on dopamine dynamics in the striatum. Analysis of circadian patterns using automated on-line microdialysis.苯丙胺戒断对纹状体多巴胺动力学影响的区域差异。使用自动在线微透析分析昼夜节律模式。
Neuropsychopharmacology. 1996 May;14(5):325-37. doi: 10.1016/0893-133X(95)00141-Y.
5
Behavioral and neurochemical changes in the dopaminergic system after repeated cocaine administration.反复给予可卡因后多巴胺能系统的行为和神经化学变化。
Mol Neurobiol. 1995 Aug-Dec;11(1-3):55-66. doi: 10.1007/BF02740684.
6
Invariance of the density of dopamine uptake sites and dopamine metabolism in the rat brain after a chronic treatment with the dopamine uptake inhibitor GBR 12783.用多巴胺摄取抑制剂GBR 12783长期治疗后大鼠脑中多巴胺摄取位点密度和多巴胺代谢的不变性
J Neural Transm Gen Sect. 1994;98(3):209-15. doi: 10.1007/BF01276537.
钠敏感型可卡因与大鼠纹状体膜的结合：与多巴胺摄取位点的可能关系。
J Neurochem. 1983 Jul;41(1):172-8. doi: 10.1111/j.1471-4159.1983.tb13666.x.
4
Comparison of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat.慢性氟哌啶醇治疗对大鼠A9和A10多巴胺能神经元影响的比较。
Life Sci. 1983 Feb 28;32(9):983-93. doi: 10.1016/0024-3205(83)90929-3.
5
[3H]mazindol binding associated with neuronal dopamine and norepinephrine uptake sites.与神经元多巴胺和去甲肾上腺素摄取位点相关的[3H]马吲哚结合
Mol Pharmacol. 1984 Jul;26(1):35-44.
6
Sodium dependent [3H]cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinsons disease.大鼠纹状体和人类壳核中与多巴胺摄取位点相关的钠依赖性[3H]可卡因结合在多巴胺能去神经支配后以及帕金森病中减少。
Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):227-35. doi: 10.1007/BF00501873.
7
Effects of subchronic haloperidol and sulpiride on regional brain dopamine metabolism in the rat.亚慢性氟哌啶醇和舒必利对大鼠脑区多巴胺代谢的影响。
Eur J Pharmacol. 1986 Oct 7;129(3):401-4. doi: 10.1016/0014-2999(86)90457-7.
8
Effect of chronic treatment with SCH 23390 and haloperidol on spontaneous activity of dopamine neurones in substantia nigra pars compacta (SNC) and ventral tegmental area (VTA) in rats.SCH 23390和氟哌啶醇长期治疗对大鼠黑质致密部（SNC）和腹侧被盖区（VTA）多巴胺神经元自发活动的影响。
Eur J Pharmacol. 1988 Jan 12;145(2):239-43. doi: 10.1016/0014-2999(88)90238-5.
9
[3H]GBR 12935 binding to dopamine uptake sites: subcellular localization and reduction in Parkinson's disease and progressive supranuclear palsy.[3H]GBR 12935与多巴胺摄取位点的结合：亚细胞定位以及在帕金森病和进行性核上性麻痹中的减少
Eur J Pharmacol. 1988 Nov 8;156(3):331-40. doi: 10.1016/0014-2999(88)90278-6.
10
Binding characteristics of the dopamine uptake inhibitor [3H]nomifensine to striatal membranes.多巴胺摄取抑制剂[3H]诺米芬辛与纹状体膜的结合特性
Biochem Pharmacol. 1985 Apr 15;34(8):1137-44. doi: 10.1016/0006-2952(85)90486-1.