Heraud-Farlow Jacki E, Kiebler Michael A
Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, 1030 Vienna, Austria.
Department of Anatomy and Cell Biology, Ludwig-Maximilians-University, 80336 Munich, Germany.
Trends Neurosci. 2014 Sep;37(9):470-9. doi: 10.1016/j.tins.2014.05.009. Epub 2014 Jul 7.
Staufen (Stau) proteins belong to a family of RNA-binding proteins (RBPs) that are important for RNA localisation in many organisms. In this review we discuss recent findings on the conserved role played by Stau during both the early differentiation of neurons and in the synaptic plasticity of mature neurons. Recent molecular data suggest mechanisms for how Stau2 regulates mRNA localisation, mRNA stability, translation, and ribonucleoprotein (RNP) assembly. We offer a perspective on how this multifunctional RBP has been adopted to regulate mRNA localisation under several different cellular and developmental conditions.
Staufen（Stau）蛋白属于RNA结合蛋白（RBP）家族，在许多生物体中对RNA定位起着重要作用。在本综述中，我们讨论了关于Stau在神经元早期分化和成熟神经元突触可塑性过程中所起保守作用的最新发现。最近的分子数据揭示了Stau2调节mRNA定位、mRNA稳定性、翻译和核糖核蛋白（RNP）组装的机制。我们针对这种多功能RBP如何在几种不同的细胞和发育条件下被用于调节mRNA定位提供了一种观点。
