Division of Clinical Psychology and Psychotherapy, Philipps Universität, Marburg, Germany.
Institute for Laboratory Medicine, Ludwig-Maximilian-Universität, Munich, Germany.
J Affect Disord. 2014 Sep;166:156-64. doi: 10.1016/j.jad.2014.04.060. Epub 2014 May 5.
Previous research indicates that physical activity may alter the number of immune cells. We examined whether increasing or decreasing the level of physical activity affects circulating lymphocyte and monocyte counts in patients with somatization syndromes and patients with major depression.
Thirty-eight participants with major depression, 26 participants with somatization syndromes and 47 healthy controls participated in the study. Using an experimental within-subject design, participants were involved in 1 week of increased physical activity (daily exercise sessions) and 1 week of reduced physical activity. Counts of total lymphocytes, lymphocyte subsets and monocytes were determined before and after each trial. Linear mixed models adjusted for sex, body mass index, age, fitness status and the order of trials were used for longitudinal data analysis.
One week of exercise increases the number of monocytes in healthy controls (p<.05), but not in patients with somatization syndromes or patients with major depression. In addition, after 1 week of exercise, depressive symptoms were reduced in patients with major depression (p<.05) while somatoform symptoms were reduced (p<.05) in both clinical groups. Baseline comparisons and mixed models indicated reduced T helper cell counts in patients with somatization syndromes.
Relatively small sample size. The time of physical activity was relatively short and restricted to low-graded exercise.
This study demonstrates a blunted mobilization of monocytes by exercise in both patients with somatization syndromes and patients with major depression. In addition, even one week of exercise reduces somatoform and depressive symptoms.
先前的研究表明，身体活动可能会改变免疫细胞的数量。我们研究了增加或减少身体活动水平是否会影响躯体化综合征患者和重度抑郁症患者的循环淋巴细胞和单核细胞计数。
38 名重度抑郁症患者、26 名躯体化综合征患者和 47 名健康对照者参与了这项研究。采用实验性自身对照设计，参与者在一周内增加身体活动（每天进行运动）和一周内减少身体活动。在每次试验前后，都测定了总淋巴细胞、淋巴细胞亚群和单核细胞的计数。采用线性混合模型对性别、体重指数、年龄、健康状况和试验顺序进行调整，对纵向数据进行分析。
一周的运动增加了健康对照组中单核细胞的数量（p<.05），但对躯体化综合征患者或重度抑郁症患者没有影响。此外，在进行一周的运动后，重度抑郁症患者的抑郁症状减轻（p<.05），而两个临床组的躯体化症状均减轻（p<.05）。基线比较和混合模型表明，躯体化综合征患者的辅助性 T 细胞计数减少。
样本量相对较小。身体活动的时间相对较短，且仅限于低强度运动。
这项研究表明，躯体化综合征患者和重度抑郁症患者的运动对单核细胞的动员作用减弱。此外，即使是一周的运动也可以减轻躯体化和抑郁症状。
