Bissell Lianne, Tibrewal Saket, Sahni Varun, Khan Wasim S
Peninsula Orthopaedics Research Institute, 812 Pittwater Road, Dee Why, NSW 2099, Australia.
Curr Stem Cell Res Ther. 2015;10(1):19-25. doi: 10.2174/1574888x09666140710102002.
Platelet Rich Plasma (PRP) and growth factors have had encouraging results in several surgical specialties. Their use in orthopaedics is increasing and has been trialed in fracture management, spinal fusion and tendon and ligament healing. Anterior cruciate ligament (ACL) injuries are a significant economic burden and often require surgical reconstruction. This review article used laboratory and clinical studies to evaluate the effectiveness of PRP and growth factors as an adjunct to ACL reconstruction. Overall, the results of studies to date have been disappointing especially given the success in other specialties. PRP has been relatively successful in improving vascularization within the tibial tunnel but less so in the femoral tunnels. The targeting of specific growth factors seems to show more promise than generic PRP injections with vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and transforming growth factor-beta (TGF-β) showing the most significant results in graft healing. Further trials are still required before a definitive conclusion can be reached.
富血小板血浆（PRP）和生长因子在多个外科专业领域已取得了令人鼓舞的成果。它们在骨科的应用日益增多，并已在骨折治疗、脊柱融合以及肌腱和韧带愈合方面进行了试验。前交叉韧带（ACL）损伤是一项重大的经济负担，且通常需要进行手术重建。这篇综述文章利用实验室和临床研究来评估PRP和生长因子作为ACL重建辅助手段的有效性。总体而言，迄今为止的研究结果令人失望，尤其是考虑到在其他专业领域所取得的成功。PRP在改善胫骨隧道内的血管化方面相对较为成功，但在股骨隧道内的效果则较差。靶向特定生长因子似乎比普通的PRP注射更具前景，其中血管内皮生长因子（VEGF）、血小板衍生生长因子（PDGF）和转化生长因子-β（TGF-β）在移植物愈合方面显示出最为显著的效果。在得出明确结论之前，仍需要进一步的试验。
